Scholars@Duke publication: Development of a DNA biochip: Principle and applications

Development of a DNA biochip: Principle and applications

Publication , Journal Article

Vo-Dinh, T

Published in: Sensors and Actuators, B: Chemical

August 31, 1998

This paper provides an overview of the operating principle of a DNA biochip based on integrated circuit for use in biomedical diagnostics. The device is a self-contained system with photosensors, amplifiers, discriminators and logic circuitry on board. The development and evaluation of various microchip system components of the genosensor are reviewed. Fluorescence detection of gene probes specific to DNA sequences related to pathogens such as the human immuno-deficiency virus 1 (HIV1) system illustrates the usefulness and potential of the DNA biochip technology for rapid and cost-effective medical diagnostics. Potential usefulness of the DNA biochip in clinical applications and functional genomics research is discussed. © 1998 Elsevier Science S.A. All rights reserved.

Duke Scholars

Author Tuan Vo-Dinh Biomedical Engineering

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Published In

Sensors and Actuators, B: Chemical

DOI

10.1016/S0925-4005(98)00182-8

ISSN

0925-4005

Publication Date

August 31, 1998

Volume

Issue

1-3

Start / End Page

52 / 59

Related Subject Headings

Analytical Chemistry
4016 Materials engineering
4004 Chemical engineering
3401 Analytical chemistry
0912 Materials Engineering
0301 Analytical Chemistry
0205 Optical Physics

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Vo-Dinh, T. (1998). Development of a DNA biochip: Principle and applications. Sensors and Actuators, B: Chemical, 51(1–3), 52–59. https://doi.org/10.1016/S0925-4005(98)00182-8

Vo-Dinh, T. “Development of a DNA biochip: Principle and applications.” Sensors and Actuators, B: Chemical 51, no. 1–3 (August 31, 1998): 52–59. https://doi.org/10.1016/S0925-4005(98)00182-8.

Vo-Dinh T. Development of a DNA biochip: Principle and applications. Sensors and Actuators, B: Chemical. 1998 Aug 31;51(1–3):52–9.

Vo-Dinh, T. “Development of a DNA biochip: Principle and applications.” Sensors and Actuators, B: Chemical, vol. 51, no. 1–3, Aug. 1998, pp. 52–59. Scopus, doi:10.1016/S0925-4005(98)00182-8.

Vo-Dinh T. Development of a DNA biochip: Principle and applications. Sensors and Actuators, B: Chemical. 1998 Aug 31;51(1–3):52–59.

Published In

Sensors and Actuators, B: Chemical

DOI

10.1016/S0925-4005(98)00182-8

ISSN

0925-4005

Publication Date

August 31, 1998

Volume

Issue

1-3

Start / End Page

52 / 59

Related Subject Headings

Analytical Chemistry
4016 Materials engineering
4004 Chemical engineering
3401 Analytical chemistry
0912 Materials Engineering
0301 Analytical Chemistry
0205 Optical Physics