Skip to main content
Journal cover image

Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy.

Publication ,  Journal Article
Saker, F; Voora, DM; Mahajan, SD; Kiliç, I; Ismail-Beigi, F; Kalhan, SC
Published in: Metabolism
June 1999

The effect of prolonged exposure to a reduced fraction of inspired oxygen ([FiO2] 0.17 for 3 days) on maternal glucose kinetics, placental glucose transporters GLUT1 and GLUT3, and fetal growth was examined in rat pregnancy. Arterial and venous catheters were placed 3 days before the study. [3-(3)H]glucose tracer and deuterium labeling of water were used to measure the rates of glucose turnover and gluconeogenesis (GNG), respectively. Glucose uptake by maternal tissues was measured using [14C]2-deoxyglucose. Exposure to a reduced FiO2 resulted in a significant decrease (mean +/- SE) in fetal weight (room air, 4.02 +/- 0.04 g; 0.17 FiO2, 3.27 +/- 0.6 g, P < .02). There was a significant increase in the maternal-fetal glucose gradient (maternal-fetal glucose ratio: room air, 1.48 +/- 0.11; 0.17 FiO2, 2.26 +/- 0.24, P < .05), but there was no change in the maternal or fetal blood lactate concentration. No significant change in maternal blood pH was observed; however, a significant decrease in the blood partial pressure of O2 (PO2) occurred (room air, 97 +/- 0.5 torr; 0.17 FiO2, 81 +/- 1.8) on day 3. There was no change in the rate of turnover of glucose or GNG in the maternal compartment, nor was there any effect on glucose uptake by the maternal tissues. Placental GLUT1 and GLUT3 mRNA were not different in the control or experimental animals. We conclude that a mild reduction in the FiO2 for 3 days in rat pregnancy results in a significant fetal growth restriction that is not related to any observed alteration in maternal glucose metabolism. The lower glucose concentration in the fetal blood may be the consequence of an increase in fetal glucose metabolism, thereby resulting in an increased maternal-fetal gradient of glucose.

Duke Scholars

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

June 1999

Volume

48

Issue

6

Start / End Page

738 / 744

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pregnancy, Animal
  • Pregnancy
  • Oxygen
  • Nerve Tissue Proteins
  • Monosaccharide Transport Proteins
  • Lactic Acid
  • Kinetics
  • Hypoxia
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Saker, F., Voora, D. M., Mahajan, S. D., Kiliç, I., Ismail-Beigi, F., & Kalhan, S. C. (1999). Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy. Metabolism, 48(6), 738–744. https://doi.org/10.1016/s0026-0495(99)90173-7
Saker, F., D. M. Voora, S. D. Mahajan, I. Kiliç, F. Ismail-Beigi, and S. C. Kalhan. “Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy.Metabolism 48, no. 6 (June 1999): 738–44. https://doi.org/10.1016/s0026-0495(99)90173-7.
Saker F, Voora DM, Mahajan SD, Kiliç I, Ismail-Beigi F, Kalhan SC. Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy. Metabolism. 1999 Jun;48(6):738–44.
Saker, F., et al. “Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy.Metabolism, vol. 48, no. 6, June 1999, pp. 738–44. Pubmed, doi:10.1016/s0026-0495(99)90173-7.
Saker F, Voora DM, Mahajan SD, Kiliç I, Ismail-Beigi F, Kalhan SC. Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy. Metabolism. 1999 Jun;48(6):738–744.
Journal cover image

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

June 1999

Volume

48

Issue

6

Start / End Page

738 / 744

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pregnancy, Animal
  • Pregnancy
  • Oxygen
  • Nerve Tissue Proteins
  • Monosaccharide Transport Proteins
  • Lactic Acid
  • Kinetics
  • Hypoxia