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Association of depressive symptoms with reduced baroreflex cardiac control in coronary artery disease.

Publication ,  Journal Article
Watkins, LL; Grossman, P
Published in: Am Heart J
March 1999

BACKGROUND: Although depression has been associated with cardiac death in coronary artery disease (CAD), little is known about the effects of depression on autonomic nervous system control of heart rate. This study evaluated whether depressive symptomatology is associated with impaired baroreflex sensitivity (BRS) in patients with CAD. METHODS AND RESULTS: BRS was assessed in 66 patients with stable CAD by using cross-spectral analysis to measure baroreceptor-mediated R-R interval oscillations. Depressive symptomatology was determined with the Beck Depression Inventory, with lower (scores <3, n = 14) and upper (scores >9, n = 16) quartiles of scores used to define groups with low and high depressive symptomatology, respectively. Comparison of the two groups showed that age-adjusted BRS was reduced in the patients with high depressive symptomatology when compared with patients with low depressive symptomatology (4.5 +/- 2.7 vs 6.5 +/- 2.8 ms/mm Hg; P <. 05). CONCLUSIONS: The current findings show that patients with CAD and depressive symptomatology have reduced BRS. Future studies are needed to examine whether reduced baroreflex cardiac control predicts cardiac risk in patients with CAD and depressive symptomatology.

Duke Scholars

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

March 1999

Volume

137

Issue

3

Start / End Page

453 / 457

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Signal Processing, Computer-Assisted
  • Risk Factors
  • Pressoreceptors
  • Middle Aged
  • Male
  • Humans
  • Heart Rate
  • Fourier Analysis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Watkins, L. L., & Grossman, P. (1999). Association of depressive symptoms with reduced baroreflex cardiac control in coronary artery disease. Am Heart J, 137(3), 453–457. https://doi.org/10.1016/s0002-8703(99)70491-6
Watkins, L. L., and P. Grossman. “Association of depressive symptoms with reduced baroreflex cardiac control in coronary artery disease.Am Heart J 137, no. 3 (March 1999): 453–57. https://doi.org/10.1016/s0002-8703(99)70491-6.
Watkins, L. L., and P. Grossman. “Association of depressive symptoms with reduced baroreflex cardiac control in coronary artery disease.Am Heart J, vol. 137, no. 3, Mar. 1999, pp. 453–57. Pubmed, doi:10.1016/s0002-8703(99)70491-6.
Journal cover image

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

March 1999

Volume

137

Issue

3

Start / End Page

453 / 457

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Signal Processing, Computer-Assisted
  • Risk Factors
  • Pressoreceptors
  • Middle Aged
  • Male
  • Humans
  • Heart Rate
  • Fourier Analysis