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Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children.

Publication ,  Journal Article
Rubach, MP; Mukemba, J; Florence, S; John, B; Crookston, B; Lopansri, BK; Yeo, TW; Piera, KA; Alder, SC; Weinberg, JB; Anstey, NM; Granger, DL ...
Published in: PLoS One
2012

Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) concentrations, a measure of parasite biomass, have been correlated with malaria severity in adults, but not yet in children. We measured plasma PfHRP-2 in Tanzanian children with uncomplicated (n = 61) and cerebral malaria (n = 45; 7 deaths). Median plasma PfHRP-2 concentrations were higher in cerebral malaria (1008 [IQR 342-2572] ng/mL) than in uncomplicated malaria (465 [IQR 36-1426] ng/mL; p = 0.017). In cerebral malaria, natural log plasma PfHRP-2 was associated with coma depth (r = -0.42; p = 0.006) and mortality (OR: 3.0 [95% CI 1.03-8.76]; p = 0.04). In this relatively small cohort study in a mesoendemic transmission area of Africa, plasma PfHRP-2 was associated with pediatric malaria severity and mortality. Further studies among children in areas of Africa with higher malaria transmission and among children with different clinical manifestations of severe malaria will help determine the wider utility of quantitative PfHRP-2 as a measure of parasite biomass and prognosis in sub-Saharan Africa.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2012

Volume

7

Issue

5

Start / End Page

e35985

Location

United States

Related Subject Headings

  • Tanzania
  • Protozoan Proteins
  • Plasmodium falciparum
  • Male
  • Malaria
  • Infant
  • Humans
  • Genetic Association Studies
  • General Science & Technology
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Rubach, M. P., Mukemba, J., Florence, S., John, B., Crookston, B., Lopansri, B. K., … Mwaikambo, E. D. (2012). Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children. PLoS One, 7(5), e35985. https://doi.org/10.1371/journal.pone.0035985
Rubach, Matthew P., Jackson Mukemba, Salvatore Florence, Bernard John, Benjamin Crookston, Bert K. Lopansri, Tsin W. Yeo, et al. “Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children.PLoS One 7, no. 5 (2012): e35985. https://doi.org/10.1371/journal.pone.0035985.
Rubach MP, Mukemba J, Florence S, John B, Crookston B, Lopansri BK, et al. Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children. PLoS One. 2012;7(5):e35985.
Rubach, Matthew P., et al. “Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children.PLoS One, vol. 7, no. 5, 2012, p. e35985. Pubmed, doi:10.1371/journal.pone.0035985.
Rubach MP, Mukemba J, Florence S, John B, Crookston B, Lopansri BK, Yeo TW, Piera KA, Alder SC, Weinberg JB, Anstey NM, Granger DL, Mwaikambo ED. Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children. PLoS One. 2012;7(5):e35985.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2012

Volume

7

Issue

5

Start / End Page

e35985

Location

United States

Related Subject Headings

  • Tanzania
  • Protozoan Proteins
  • Plasmodium falciparum
  • Male
  • Malaria
  • Infant
  • Humans
  • Genetic Association Studies
  • General Science & Technology
  • Female