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Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling.

Publication ,  Journal Article
Welsh, KA; Gold, PE
Published in: Behav Neural Biol
March 1984

Repeated daily electrical stimulation of the amygdala can lead to a progressive increase in brain and behavioral seizures. This phenomenon, termed kindling, has been viewed as a model for epileptogenesis. The results reported here demonstrate that a single systemic epinephrine injection can significantly retard such epileptogenesis for a period of at least several days. These findings suggest that peripheral catecholamines, responding either to stress near the time of seizure initiation or to treatments administered at that time, may be important in regulating the development of epileptic states. In addition, the results indicate that an acute episode of high plasma epinephrine levels may result in a durable modification of brain function.

Duke Scholars

Published In

Behav Neural Biol

DOI

ISSN

0163-1047

Publication Date

March 1984

Volume

40

Issue

2

Start / End Page

179 / 185

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Male
  • Kindling, Neurologic
  • Epinephrine
  • Epilepsy
  • Depression, Chemical
  • Catecholamines
  • Anticonvulsants
  • Animals
 

Citation

APA
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ICMJE
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Welsh, K. A., & Gold, P. E. (1984). Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling. Behav Neural Biol, 40(2), 179–185. https://doi.org/10.1016/s0163-1047(84)90279-6
Welsh, K. A., and P. E. Gold. “Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling.Behav Neural Biol 40, no. 2 (March 1984): 179–85. https://doi.org/10.1016/s0163-1047(84)90279-6.
Welsh, K. A., and P. E. Gold. “Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling.Behav Neural Biol, vol. 40, no. 2, Mar. 1984, pp. 179–85. Pubmed, doi:10.1016/s0163-1047(84)90279-6.

Published In

Behav Neural Biol

DOI

ISSN

0163-1047

Publication Date

March 1984

Volume

40

Issue

2

Start / End Page

179 / 185

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Male
  • Kindling, Neurologic
  • Epinephrine
  • Epilepsy
  • Depression, Chemical
  • Catecholamines
  • Anticonvulsants
  • Animals