Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling.
Publication
, Journal Article
Welsh, KA; Gold, PE
Published in: Behav Neural Biol
March 1984
Repeated daily electrical stimulation of the amygdala can lead to a progressive increase in brain and behavioral seizures. This phenomenon, termed kindling, has been viewed as a model for epileptogenesis. The results reported here demonstrate that a single systemic epinephrine injection can significantly retard such epileptogenesis for a period of at least several days. These findings suggest that peripheral catecholamines, responding either to stress near the time of seizure initiation or to treatments administered at that time, may be important in regulating the development of epileptic states. In addition, the results indicate that an acute episode of high plasma epinephrine levels may result in a durable modification of brain function.
Duke Scholars
Published In
Behav Neural Biol
DOI
ISSN
0163-1047
Publication Date
March 1984
Volume
40
Issue
2
Start / End Page
179 / 185
Location
United States
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Male
- Kindling, Neurologic
- Epinephrine
- Epilepsy
- Depression, Chemical
- Catecholamines
- Anticonvulsants
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Welsh, K. A., & Gold, P. E. (1984). Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling. Behav Neural Biol, 40(2), 179–185. https://doi.org/10.1016/s0163-1047(84)90279-6
Welsh, K. A., and P. E. Gold. “Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling.” Behav Neural Biol 40, no. 2 (March 1984): 179–85. https://doi.org/10.1016/s0163-1047(84)90279-6.
Welsh KA, Gold PE. Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling. Behav Neural Biol. 1984 Mar;40(2):179–85.
Welsh, K. A., and P. E. Gold. “Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling.” Behav Neural Biol, vol. 40, no. 2, Mar. 1984, pp. 179–85. Pubmed, doi:10.1016/s0163-1047(84)90279-6.
Welsh KA, Gold PE. Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling. Behav Neural Biol. 1984 Mar;40(2):179–185.
Published In
Behav Neural Biol
DOI
ISSN
0163-1047
Publication Date
March 1984
Volume
40
Issue
2
Start / End Page
179 / 185
Location
United States
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Male
- Kindling, Neurologic
- Epinephrine
- Epilepsy
- Depression, Chemical
- Catecholamines
- Anticonvulsants
- Animals