Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas.
Publication
, Journal Article
Abrams, RA; Winter, KA; Regine, WF; Safran, H; Hoffman, JP; Lustig, R; Konski, AA; Benson, AB; Macdonald, JS; Rich, TA; Willett, CG
Published in: Int J Radiat Oncol Biol Phys
February 1, 2012
PURPOSE: In Radiation Therapy Oncology Group 9704, as previously published, patients with resected pancreatic adenocarcinoma received continuous infusion 5-FU and concurrent radiotherapy (5FU-RT). 5FU-RT treatment was preceded and followed by randomly assigned chemotherapy, either 5-FU or gemcitabine. This analysis explored whether failure to adhere to specified RT guidelines influenced survival and/or toxicity. METHODS AND MATERIALS: RT requirements were protocol specified. Adherence was scored as per protocol (PP) or less than per protocol (
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Published In
Int J Radiat Oncol Biol Phys
DOI
EISSN
1879-355X
Publication Date
February 1, 2012
Volume
82
Issue
2
Start / End Page
809 / 816
Location
United States
Related Subject Headings
- Survival Analysis
- Pancreatic Neoplasms
- Oncology & Carcinogenesis
- Multivariate Analysis
- Middle Aged
- Male
- Humans
- Guideline Adherence
- Gemcitabine
- Fluorouracil
Citation
APA
Chicago
ICMJE
MLA
NLM
Abrams, R. A., Winter, K. A., Regine, W. F., Safran, H., Hoffman, J. P., Lustig, R., … Willett, C. G. (2012). Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys, 82(2), 809–816. https://doi.org/10.1016/j.ijrobp.2010.11.039
Abrams, Ross A., Kathryn A. Winter, William F. Regine, Howard Safran, John P. Hoffman, Robert Lustig, Andre A. Konski, et al. “Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas.” Int J Radiat Oncol Biol Phys 82, no. 2 (February 1, 2012): 809–16. https://doi.org/10.1016/j.ijrobp.2010.11.039.
Abrams RA, Winter KA, Regine WF, Safran H, Hoffman JP, Lustig R, et al. Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):809–16.
Abrams, Ross A., et al. “Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas.” Int J Radiat Oncol Biol Phys, vol. 82, no. 2, Feb. 2012, pp. 809–16. Pubmed, doi:10.1016/j.ijrobp.2010.11.039.
Abrams RA, Winter KA, Regine WF, Safran H, Hoffman JP, Lustig R, Konski AA, Benson AB, Macdonald JS, Rich TA, Willett CG. Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):809–816.
Published In
Int J Radiat Oncol Biol Phys
DOI
EISSN
1879-355X
Publication Date
February 1, 2012
Volume
82
Issue
2
Start / End Page
809 / 816
Location
United States
Related Subject Headings
- Survival Analysis
- Pancreatic Neoplasms
- Oncology & Carcinogenesis
- Multivariate Analysis
- Middle Aged
- Male
- Humans
- Guideline Adherence
- Gemcitabine
- Fluorouracil