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Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas.

Publication ,  Journal Article
Abrams, RA; Winter, KA; Regine, WF; Safran, H; Hoffman, JP; Lustig, R; Konski, AA; Benson, AB; Macdonald, JS; Rich, TA; Willett, CG
Published in: Int J Radiat Oncol Biol Phys
February 1, 2012

PURPOSE: In Radiation Therapy Oncology Group 9704, as previously published, patients with resected pancreatic adenocarcinoma received continuous infusion 5-FU and concurrent radiotherapy (5FU-RT). 5FU-RT treatment was preceded and followed by randomly assigned chemotherapy, either 5-FU or gemcitabine. This analysis explored whether failure to adhere to specified RT guidelines influenced survival and/or toxicity. METHODS AND MATERIALS: RT requirements were protocol specified. Adherence was scored as per protocol (PP) or less than per protocol (

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Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

February 1, 2012

Volume

82

Issue

2

Start / End Page

809 / 816

Location

United States

Related Subject Headings

  • Survival Analysis
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Guideline Adherence
  • Gemcitabine
  • Fluorouracil
 

Citation

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Abrams, R. A., Winter, K. A., Regine, W. F., Safran, H., Hoffman, J. P., Lustig, R., … Willett, C. G. (2012). Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys, 82(2), 809–816. https://doi.org/10.1016/j.ijrobp.2010.11.039
Abrams, Ross A., Kathryn A. Winter, William F. Regine, Howard Safran, John P. Hoffman, Robert Lustig, Andre A. Konski, et al. “Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas.Int J Radiat Oncol Biol Phys 82, no. 2 (February 1, 2012): 809–16. https://doi.org/10.1016/j.ijrobp.2010.11.039.
Abrams RA, Winter KA, Regine WF, Safran H, Hoffman JP, Lustig R, Konski AA, Benson AB, Macdonald JS, Rich TA, Willett CG. Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):809–816.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

February 1, 2012

Volume

82

Issue

2

Start / End Page

809 / 816

Location

United States

Related Subject Headings

  • Survival Analysis
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Guideline Adherence
  • Gemcitabine
  • Fluorouracil