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Outcomes in a series of 103 retroperitoneal sarcomas.

Publication ,  Journal Article
Pierie, J-PEN; Betensky, RA; Choudry, U; Willett, CG; Souba, WW; Ott, MJ
Published in: Eur J Surg Oncol
December 2006

AIMS: To report the effect on outcome of selection in patients receiving intra-operative electron beam radiation (IOERT) and external beam radiation therapy (EBRT). METHODS: One hundred and three patients treated for primary RS were studied. Median follow-up was 27 months. Clinical presentation, tumor characteristics, and treatment methods were analyzed to determine impact on survival and recurrence and if selection was occurring. RESULTS: Mean age was 55+/-17 years. Mean tumor size was 15+/-6cm and 88 were high-grade. Complete gross tumor resection (CR) occurred in 62 patients and improved survival vs. both debulking (p=0.0005) and biopsy (p<0.0001). The 5- and 10-year survival rates were 62% and 52% for those with CR vs. 29% and 20% after incomplete resection. Among the 62 CR patients, there was selection to receive additional EBRT+/-IOERT in patients with high-grade tumors (p=0.005) and/or microscopically positive margins (p=0.011). In these high-risk patients there was a trend for IOERT to further augment survival vs. EBRT alone and to increase the time to both local and distant recurrences (p=0.036). CONCLUSIONS: Complete gross resection is the primary form of curative treatment for retroperitoneal sarcomas. Selection led to patients with high-risk tumors receiving additional radiation therapy. There appears to be a beneficial effect of IOERT plus EBRT in these high-risk patients after complete tumor resection.

Duke Scholars

Published In

Eur J Surg Oncol

DOI

ISSN

0748-7983

Publication Date

December 2006

Volume

32

Issue

10

Start / End Page

1235 / 1241

Location

England

Related Subject Headings

  • Survival Rate
  • Sarcoma
  • Retroperitoneal Neoplasms
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Intraoperative Period
  • Humans
 

Citation

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ICMJE
MLA
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Pierie, J.-P., Betensky, R. A., Choudry, U., Willett, C. G., Souba, W. W., & Ott, M. J. (2006). Outcomes in a series of 103 retroperitoneal sarcomas. Eur J Surg Oncol, 32(10), 1235–1241. https://doi.org/10.1016/j.ejso.2006.07.002
Pierie, J. -. P. E. N., R. A. Betensky, U. Choudry, C. G. Willett, W. W. Souba, and M. J. Ott. “Outcomes in a series of 103 retroperitoneal sarcomas.Eur J Surg Oncol 32, no. 10 (December 2006): 1235–41. https://doi.org/10.1016/j.ejso.2006.07.002.
Pierie J-PEN, Betensky RA, Choudry U, Willett CG, Souba WW, Ott MJ. Outcomes in a series of 103 retroperitoneal sarcomas. Eur J Surg Oncol. 2006 Dec;32(10):1235–41.
Pierie, J. .. P. E. N., et al. “Outcomes in a series of 103 retroperitoneal sarcomas.Eur J Surg Oncol, vol. 32, no. 10, Dec. 2006, pp. 1235–41. Pubmed, doi:10.1016/j.ejso.2006.07.002.
Pierie J-PEN, Betensky RA, Choudry U, Willett CG, Souba WW, Ott MJ. Outcomes in a series of 103 retroperitoneal sarcomas. Eur J Surg Oncol. 2006 Dec;32(10):1235–1241.
Journal cover image

Published In

Eur J Surg Oncol

DOI

ISSN

0748-7983

Publication Date

December 2006

Volume

32

Issue

10

Start / End Page

1235 / 1241

Location

England

Related Subject Headings

  • Survival Rate
  • Sarcoma
  • Retroperitoneal Neoplasms
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Intraoperative Period
  • Humans