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Renal complications secondary to radiation treatment of upper abdominal malignancies.

Publication ,  Journal Article
Willett, CG; Tepper, JE; Orlow, EL; Shipley, WU
Published in: Int J Radiat Oncol Biol Phys
September 1986

A retrospective review of all patients undergoing radiotherapy for carcinoma of the colon, pancreas, stomach, small bowel and bile ducts, lymphomas of the stomach, and other GI sites and retroperitoneal sarcomas was completed to assess the effects of secondary irradiation on the kidney. Eighty-six adult patients were identified who were treated with curative intent, received greater than 50% unilateral kidney irradiation to doses of at least 2600 cGy and survived for 1 year or more. Following treatment, the clinical course, blood pressure, addition of anti-hypertensive medications, serum creatinine and creatinine clearance were determined. Creatinine clearance was calculated by the formula: creatinine clearance equals [(140-age) X (weight in kilograms)] divided by (72 X serum creatinine) which has a close correlation to creatinine clearances measured by 24 hr. urine measurements. The percent change in creatinine clearance from pre-treatment values was analyzed. Of the thirteen patients with pre-radiotherapy hypertension, four required an increase in the number of medications for control and nine required no change in medication. Two patients developed hypertension in follow-up, one controlled with medication and the other malignant hypertension. Acute or chronic renal failure was not observed in any patient. The serum creatinine for all 86 patients prior to radiation therapy was below 2 mg/100 ml; in follow-up it rose to between 2.2-2.9 mg/100 ml. in five patients. The mean creatinine clearance for all 86 patients prior to radiotherapy was 77 ml/minute and for 16 patients with at least 5 years of follow-up it was 62 ml/minute. The mean percent decrease in creatinine clearance appeared to correspond to the percentage of kidney irradiated: for 38 patients with only 50% of the kidney irradiated the mean percent decrease was 10%, whereas for 31 patients having 90 to 100% of the kidney treated the decrease was 24%. Although physiologic changes were seen in patients receiving 50% or more unilateral kidney irradiation, the development of significant clinical sequelae was limited to one patient.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

September 1986

Volume

12

Issue

9

Start / End Page

1601 / 1604

Location

United States

Related Subject Headings

  • Radiotherapy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Kidney
  • Humans
  • Female
  • Aged, 80 and over
  • Aged
  • Adult
 

Citation

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Willett, C. G., Tepper, J. E., Orlow, E. L., & Shipley, W. U. (1986). Renal complications secondary to radiation treatment of upper abdominal malignancies. Int J Radiat Oncol Biol Phys, 12(9), 1601–1604. https://doi.org/10.1016/0360-3016(86)90284-1
Willett, C. G., J. E. Tepper, E. L. Orlow, and W. U. Shipley. “Renal complications secondary to radiation treatment of upper abdominal malignancies.Int J Radiat Oncol Biol Phys 12, no. 9 (September 1986): 1601–4. https://doi.org/10.1016/0360-3016(86)90284-1.
Willett CG, Tepper JE, Orlow EL, Shipley WU. Renal complications secondary to radiation treatment of upper abdominal malignancies. Int J Radiat Oncol Biol Phys. 1986 Sep;12(9):1601–4.
Willett, C. G., et al. “Renal complications secondary to radiation treatment of upper abdominal malignancies.Int J Radiat Oncol Biol Phys, vol. 12, no. 9, Sept. 1986, pp. 1601–04. Pubmed, doi:10.1016/0360-3016(86)90284-1.
Willett CG, Tepper JE, Orlow EL, Shipley WU. Renal complications secondary to radiation treatment of upper abdominal malignancies. Int J Radiat Oncol Biol Phys. 1986 Sep;12(9):1601–1604.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

September 1986

Volume

12

Issue

9

Start / End Page

1601 / 1604

Location

United States

Related Subject Headings

  • Radiotherapy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Kidney
  • Humans
  • Female
  • Aged, 80 and over
  • Aged
  • Adult