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Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood.

Publication ,  Journal Article
Wong-Goodrich, SJE; Tognoni, CM; Mellott, TJ; Glenn, MJ; Blusztajn, JK; Williams, CL
Published in: Brain research
September 2011

Choline is a vital nutrient needed during early development for both humans and rodents. Severe dietary choline deficiency during pregnancy leads to birth defects, while more limited deficiency during mid- to late pregnancy causes deficits in hippocampal plasticity in adult rodent offspring that are accompanied by cognitive deficits only when task demands are high. Because prenatal choline supplementation confers neuroprotection of the adult hippocampus against a variety of neural insults and aids memory, we hypothesized that prenatal choline deficiency may enhance vulnerability to neural injury. To examine this, adult offspring of rat dams either fed a control diet (CON) or one deficient in choline (DEF) during embryonic days 12-17 were given multiple injections (i.p.) of saline (control) or kainic acid to induce seizures and were euthanized 16 days later. Perhaps somewhat surprisingly, DEF rats were not more susceptible to seizure induction and showed similar levels of seizure-induced hippocampal histopathology, GAD expression loss, upregulated hippocampal GFAP and growth factor expression, and increased dentate cell and neuronal proliferation as that seen in CON rats. Although prenatal choline deficiency compromises adult hippocampal plasticity in the intact brain, it does not appear to exacerbate the neuropathological response to seizures in the adult hippocampus at least shortly after excitotoxic injury.

Duke Scholars

Published In

Brain research

DOI

EISSN

1872-6240

ISSN

0006-8993

Publication Date

September 2011

Volume

1413

Start / End Page

84 / 97

Related Subject Headings

  • Seizures
  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Neuroprotective Agents
  • Neurology & Neurosurgery
  • Male
  • Kainic Acid
  • Hippocampus
 

Citation

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ICMJE
MLA
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Wong-Goodrich, S. J. E., Tognoni, C. M., Mellott, T. J., Glenn, M. J., Blusztajn, J. K., & Williams, C. L. (2011). Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain Research, 1413, 84–97. https://doi.org/10.1016/j.brainres.2011.07.042
Wong-Goodrich, Sarah J. E., Christina M. Tognoni, Tiffany J. Mellott, Melissa J. Glenn, Jan K. Blusztajn, and Christina L. Williams. “Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood.Brain Research 1413 (September 2011): 84–97. https://doi.org/10.1016/j.brainres.2011.07.042.
Wong-Goodrich SJE, Tognoni CM, Mellott TJ, Glenn MJ, Blusztajn JK, Williams CL. Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain research. 2011 Sep;1413:84–97.
Wong-Goodrich, Sarah J. E., et al. “Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood.Brain Research, vol. 1413, Sept. 2011, pp. 84–97. Epmc, doi:10.1016/j.brainres.2011.07.042.
Wong-Goodrich SJE, Tognoni CM, Mellott TJ, Glenn MJ, Blusztajn JK, Williams CL. Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. Brain research. 2011 Sep;1413:84–97.
Journal cover image

Published In

Brain research

DOI

EISSN

1872-6240

ISSN

0006-8993

Publication Date

September 2011

Volume

1413

Start / End Page

84 / 97

Related Subject Headings

  • Seizures
  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Neuroprotective Agents
  • Neurology & Neurosurgery
  • Male
  • Kainic Acid
  • Hippocampus