NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Publication
, Journal Article
Stasheff, SF; Anderson, WW; Clark, S; Wilson, WA
Published in: Science (New York, N.Y.)
August 1989
In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures. Thus, a process dependent on the NMDA receptor-ionophore complex establishes a long-lasting, seizure-prone state; thereafter the seizures depend on non-NMDA receptor-ionophore mechanisms. This suggests that there is an important distinction between epileptogenesis and seizure expression and between antiepileptogenic and anticonvulsant pharmacological agents.
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Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
August 1989
Volume
245
Issue
4918
Start / End Page
648 / 651
Related Subject Headings
- Valine
- Seizures
- Receptors, Neurotransmitter
- Receptors, N-Methyl-D-Aspartate
- Rats
- N-Methylaspartate
- In Vitro Techniques
- Hippocampus
- General Science & Technology
- Evoked Potentials
Citation
APA
Chicago
ICMJE
MLA
NLM
Stasheff, S. F., Anderson, W. W., Clark, S., & Wilson, W. A. (1989). NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science (New York, N.Y.), 245(4918), 648–651. https://doi.org/10.1126/science.2569762
Stasheff, S. F., W. W. Anderson, S. Clark, and W. A. Wilson. “NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.” Science (New York, N.Y.) 245, no. 4918 (August 1989): 648–51. https://doi.org/10.1126/science.2569762.
Stasheff SF, Anderson WW, Clark S, Wilson WA. NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science (New York, NY). 1989 Aug;245(4918):648–51.
Stasheff, S. F., et al. “NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.” Science (New York, N.Y.), vol. 245, no. 4918, Aug. 1989, pp. 648–51. Epmc, doi:10.1126/science.2569762.
Stasheff SF, Anderson WW, Clark S, Wilson WA. NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science (New York, NY). 1989 Aug;245(4918):648–651.
Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
August 1989
Volume
245
Issue
4918
Start / End Page
648 / 651
Related Subject Headings
- Valine
- Seizures
- Receptors, Neurotransmitter
- Receptors, N-Methyl-D-Aspartate
- Rats
- N-Methylaspartate
- In Vitro Techniques
- Hippocampus
- General Science & Technology
- Evoked Potentials