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NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.

Publication ,  Journal Article
Stasheff, SF; Anderson, WW; Clark, S; Wilson, WA
Published in: Science (New York, N.Y.)
August 1989

In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures. Thus, a process dependent on the NMDA receptor-ionophore complex establishes a long-lasting, seizure-prone state; thereafter the seizures depend on non-NMDA receptor-ionophore mechanisms. This suggests that there is an important distinction between epileptogenesis and seizure expression and between antiepileptogenic and anticonvulsant pharmacological agents.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

August 1989

Volume

245

Issue

4918

Start / End Page

648 / 651

Related Subject Headings

  • Valine
  • Seizures
  • Receptors, Neurotransmitter
  • Receptors, N-Methyl-D-Aspartate
  • Rats
  • N-Methylaspartate
  • In Vitro Techniques
  • Hippocampus
  • General Science & Technology
  • Evoked Potentials
 

Citation

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Stasheff, S. F., Anderson, W. W., Clark, S., & Wilson, W. A. (1989). NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science (New York, N.Y.), 245(4918), 648–651. https://doi.org/10.1126/science.2569762
Stasheff, S. F., W. W. Anderson, S. Clark, and W. A. Wilson. “NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.Science (New York, N.Y.) 245, no. 4918 (August 1989): 648–51. https://doi.org/10.1126/science.2569762.
Stasheff SF, Anderson WW, Clark S, Wilson WA. NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science (New York, NY). 1989 Aug;245(4918):648–51.
Stasheff, S. F., et al. “NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.Science (New York, N.Y.), vol. 245, no. 4918, Aug. 1989, pp. 648–51. Epmc, doi:10.1126/science.2569762.
Stasheff SF, Anderson WW, Clark S, Wilson WA. NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. Science (New York, NY). 1989 Aug;245(4918):648–651.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

August 1989

Volume

245

Issue

4918

Start / End Page

648 / 651

Related Subject Headings

  • Valine
  • Seizures
  • Receptors, Neurotransmitter
  • Receptors, N-Methyl-D-Aspartate
  • Rats
  • N-Methylaspartate
  • In Vitro Techniques
  • Hippocampus
  • General Science & Technology
  • Evoked Potentials