RU486 in depression.
Publication
, Journal Article
Krishnan, KR; Reed, D; Wilson, WH; Saunders, WB; Ritchie, JC; Nemeroff, CB; Carroll, BJ
Published in: Prog Neuropsychopharmacol Biol Psychiatry
1992
RU486 is a synthetic glucocorticoid antagonist. The authors used RU486 to examine the hypothesis that the elevated plasma cortisol and ACTH in patients is due to suprahypophyseal stimulation of the anterior pituitary. Seven patients and matched controls were studied before and after the administration of RU486. RU486 produced an increase in HPA activity in depressed patients. Thus providing support for the hypothesis that there is increased suprahypophyseal stimulation of the anterior pituitary.
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Published In
Prog Neuropsychopharmacol Biol Psychiatry
DOI
ISSN
0278-5846
Publication Date
1992
Volume
16
Issue
6
Start / End Page
913 / 920
Location
England
Related Subject Headings
- Psychiatry
- Mifepristone
- Middle Aged
- Male
- Hydrocortisone
- Humans
- Female
- Dexamethasone
- Depressive Disorder
- Antidepressive Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Krishnan, K. R., Reed, D., Wilson, W. H., Saunders, W. B., Ritchie, J. C., Nemeroff, C. B., & Carroll, B. J. (1992). RU486 in depression. Prog Neuropsychopharmacol Biol Psychiatry, 16(6), 913–920. https://doi.org/10.1016/0278-5846(92)90109-r
Krishnan, K. R., D. Reed, W. H. Wilson, W. B. Saunders, J. C. Ritchie, C. B. Nemeroff, and B. J. Carroll. “RU486 in depression.” Prog Neuropsychopharmacol Biol Psychiatry 16, no. 6 (1992): 913–20. https://doi.org/10.1016/0278-5846(92)90109-r.
Krishnan KR, Reed D, Wilson WH, Saunders WB, Ritchie JC, Nemeroff CB, et al. RU486 in depression. Prog Neuropsychopharmacol Biol Psychiatry. 1992;16(6):913–20.
Krishnan, K. R., et al. “RU486 in depression.” Prog Neuropsychopharmacol Biol Psychiatry, vol. 16, no. 6, 1992, pp. 913–20. Pubmed, doi:10.1016/0278-5846(92)90109-r.
Krishnan KR, Reed D, Wilson WH, Saunders WB, Ritchie JC, Nemeroff CB, Carroll BJ. RU486 in depression. Prog Neuropsychopharmacol Biol Psychiatry. 1992;16(6):913–920.
Published In
Prog Neuropsychopharmacol Biol Psychiatry
DOI
ISSN
0278-5846
Publication Date
1992
Volume
16
Issue
6
Start / End Page
913 / 920
Location
England
Related Subject Headings
- Psychiatry
- Mifepristone
- Middle Aged
- Male
- Hydrocortisone
- Humans
- Female
- Dexamethasone
- Depressive Disorder
- Antidepressive Agents