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Regional cerebral blood flow after marijuana smoking.

Publication ,  Journal Article
Mathew, RJ; Wilson, WH; Humphreys, DF; Lowe, JV; Wiethe, KE
Published in: J Cereb Blood Flow Metab
September 1992

Regional CBF was measured with the 133Xe inhalation technique before and thrice after smoking marijuana of two strengths and placebo in 20 physically and mentally healthy male volunteers with a previous history of exposure to marijuana. They were drug-free at the time of the study. Blood pressure, pulse rate, end-tidal carbon dioxide, end-tidal carbon monoxide, and forehead skin perfusion were quantified during the CBF measurements. Blood samples were drawn for quantification of plasma levels of delta 9-tetrahydrocannabinol (THC) before and during the 2 h after smoking marijuana or placebo. Drug-induced intoxication and changes in mood were quantified with rating scales. Marijuana smoking was associated with bilateral CBF increase, which was maximal 30 min later. Greater CBF increases were seen in the frontal region and right hemisphere. No significant CBF changes were seen after placebo. Pulse rate and respiration increased significantly after marijuana but not placebo. Both marijuana and placebo smoking were associated with increased end-tidal carbon monoxide. CBF increase in both hemispheres correlated significantly with degree of intoxication, plasma levels of THC, and pulse rate.

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Published In

J Cereb Blood Flow Metab

DOI

ISSN

0271-678X

Publication Date

September 1992

Volume

12

Issue

5

Start / End Page

750 / 758

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Marijuana Smoking
  • Male
  • Humans
  • Dronabinol
  • Cerebrovascular Circulation
  • Analysis of Variance
  • Adult
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

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Mathew, R. J., Wilson, W. H., Humphreys, D. F., Lowe, J. V., & Wiethe, K. E. (1992). Regional cerebral blood flow after marijuana smoking. J Cereb Blood Flow Metab, 12(5), 750–758. https://doi.org/10.1038/jcbfm.1992.106
Mathew, R. J., W. H. Wilson, D. F. Humphreys, J. V. Lowe, and K. E. Wiethe. “Regional cerebral blood flow after marijuana smoking.J Cereb Blood Flow Metab 12, no. 5 (September 1992): 750–58. https://doi.org/10.1038/jcbfm.1992.106.
Mathew RJ, Wilson WH, Humphreys DF, Lowe JV, Wiethe KE. Regional cerebral blood flow after marijuana smoking. J Cereb Blood Flow Metab. 1992 Sep;12(5):750–8.
Mathew, R. J., et al. “Regional cerebral blood flow after marijuana smoking.J Cereb Blood Flow Metab, vol. 12, no. 5, Sept. 1992, pp. 750–58. Pubmed, doi:10.1038/jcbfm.1992.106.
Mathew RJ, Wilson WH, Humphreys DF, Lowe JV, Wiethe KE. Regional cerebral blood flow after marijuana smoking. J Cereb Blood Flow Metab. 1992 Sep;12(5):750–758.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

ISSN

0271-678X

Publication Date

September 1992

Volume

12

Issue

5

Start / End Page

750 / 758

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Marijuana Smoking
  • Male
  • Humans
  • Dronabinol
  • Cerebrovascular Circulation
  • Analysis of Variance
  • Adult
  • 3209 Neurosciences
  • 3202 Clinical sciences