Changes in cerebral blood flow and mental state after amphetamine challenge in schizophrenic patients.
Publication
, Journal Article
Mathew, RJ; Wilson, WH
Published in: Neuropsychobiology
1989
Changes in regional cerebral blood flow and behavioral and physiological indices were monitored after intravenous administration of d-amphetamine sulfate and placebo in groups of patients with schizophrenia and normal volunteers. Amphetamine administration was associated with decreased anxiety, emotional withdrawal, depressed mood, blunted affect and increased excitement in the patients. Subjects who received amphetamine showed significant increases in systolic and diastolic blood pressure and reduction in end-tidal carbon dioxide. Post-amphetamine cerebral blood flow was decreased equally in both patients and controls. The blood flow change, however, did not show any regional variations.
Duke Scholars
Published In
Neuropsychobiology
DOI
ISSN
0302-282X
Publication Date
1989
Volume
21
Issue
3
Start / End Page
117 / 123
Location
Switzerland
Related Subject Headings
- Schizophrenic Psychology
- Schizophrenia
- Psychiatry
- Mental Processes
- Male
- Humans
- Female
- Dextroamphetamine
- Cerebrovascular Circulation
- Adult
Citation
APA
Chicago
ICMJE
MLA
NLM
Mathew, R. J., & Wilson, W. H. (1989). Changes in cerebral blood flow and mental state after amphetamine challenge in schizophrenic patients. Neuropsychobiology, 21(3), 117–123. https://doi.org/10.1159/000118564
Mathew, R. J., and W. H. Wilson. “Changes in cerebral blood flow and mental state after amphetamine challenge in schizophrenic patients.” Neuropsychobiology 21, no. 3 (1989): 117–23. https://doi.org/10.1159/000118564.
Mathew RJ, Wilson WH. Changes in cerebral blood flow and mental state after amphetamine challenge in schizophrenic patients. Neuropsychobiology. 1989;21(3):117–23.
Mathew, R. J., and W. H. Wilson. “Changes in cerebral blood flow and mental state after amphetamine challenge in schizophrenic patients.” Neuropsychobiology, vol. 21, no. 3, 1989, pp. 117–23. Pubmed, doi:10.1159/000118564.
Mathew RJ, Wilson WH. Changes in cerebral blood flow and mental state after amphetamine challenge in schizophrenic patients. Neuropsychobiology. 1989;21(3):117–123.
Published In
Neuropsychobiology
DOI
ISSN
0302-282X
Publication Date
1989
Volume
21
Issue
3
Start / End Page
117 / 123
Location
Switzerland
Related Subject Headings
- Schizophrenic Psychology
- Schizophrenia
- Psychiatry
- Mental Processes
- Male
- Humans
- Female
- Dextroamphetamine
- Cerebrovascular Circulation
- Adult