Scholars@Duke publication: Expression of multiple oncogenes in human esophageal carcinomas

Expression of multiple oncogenes in human esophageal carcinomas

Publication , Journal Article

Wong, FH; Hu, CP; Chiu, JH; Huang, BS; Chang, JP; Lin, PJ; Chien, KY; Chang, CC

Published in: Cancer Investigation

1994

To study the oncogenesis of human esophageal carcinoma, the expression of a variety of oncogenes was studied in 10 esophageal carcinoma cell lines and 16 pairs of tumor and nontumor tissues removed from patients with esophageal carcinoma. Northern blot analyses using 11 different oncogene probes revealed that 5 oncogenes, i.e. c-myc, c-H-ras, c-sis, c-raf, and c-fos, were expressed. Among them, a variant c-sis mRNA transcript of 2.7 kilobase (kb) was expressed in 7 of 10 cell lines and in 9 of 16 tumor tissues. Furthermore, an overexpression and an amplification of c-myc gene was observed in some cell lines. These results suggest that multiple oncogene expression may be required for the induction, maintenance, and progression of esophageal carcinoma. The expression of a 2.7-kb transcript, of c-sis and overexpression of c-myc gene may play some role in the carcinogenesis of esophageal carcinoma.

Duke Scholars

Author Fulton Wong Ophthalmology

Published In

Cancer Investigation

Publication Date

1994

Volume

Issue

Start / End Page

121 / 131

Related Subject Headings

Oncology & Carcinogenesis
1112 Oncology and Carcinogenesis

Citation

APA

Chicago

ICMJE

MLA

NLM

Wong, F. H., Hu, C. P., Chiu, J. H., Huang, B. S., Chang, J. P., Lin, P. J., … Chang, C. C. (1994). Expression of multiple oncogenes in human esophageal carcinomas. Cancer Investigation, 12(2), 121–131.

Wong, F. H., C. P. Hu, J. H. Chiu, B. S. Huang, J. P. Chang, P. J. Lin, K. Y. Chien, and C. C. Chang. “Expression of multiple oncogenes in human esophageal carcinomas.” Cancer Investigation 12, no. 2 (1994): 121–31.

Wong FH, Hu CP, Chiu JH, Huang BS, Chang JP, Lin PJ, et al. Expression of multiple oncogenes in human esophageal carcinomas. Cancer Investigation. 1994;12(2):121–31.

Wong, F. H., et al. “Expression of multiple oncogenes in human esophageal carcinomas.” Cancer Investigation, vol. 12, no. 2, 1994, pp. 121–31.

Wong FH, Hu CP, Chiu JH, Huang BS, Chang JP, Lin PJ, Chien KY, Chang CC. Expression of multiple oncogenes in human esophageal carcinomas. Cancer Investigation. 1994;12(2):121–131.