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Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster.

Publication ,  Journal Article
Wong, F; Yuh, ZT; Schaefer, EL; Roop, BC; Ally, AH
Published in: Somat Cell Mol Genet
November 1987

We report the identification in Drosophila melanogaster of two mRNA transcripts that are derived from the transient receptor potential locus by transcription in opposite directions. The two transcripts overlap; one transcript has, as part of its 5'-untranslated sequence, the reverse complement of 442 bp of the 3' terminus of the transcript derived from the opposite DNA strand. Conceptual translation of the corresponding cDNA sequences predicted for one of the transcripts a polypeptide whose C terminus shares sequence and structural similarity with the cell-wall-binding domain of protein A from Staphylococcus aureus; for the transcript derived from the opposite DNA strand, a polypeptide of 264 amino acids was predicted, which showed no significant sequence homology with any known protein. The two transcripts have different tissue specificities: one is expressed predominantly in the eye and the other is in the body. These findings may have implications in the relationship between the organization of overlapping genes on opposite DNA strands and regulation of gene expression by antisense RNA.

Duke Scholars

Published In

Somat Cell Mol Genet

DOI

ISSN

0740-7750

Publication Date

November 1987

Volume

13

Issue

6

Start / End Page

661 / 669

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • RNA, Messenger
  • Photoreceptor Cells
  • Molecular Sequence Data
  • Genes
  • Drosophila melanogaster
  • Developmental Biology
  • DNA
  • Chromosome Mapping
  • Base Sequence
 

Citation

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ICMJE
MLA
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Wong, F., Yuh, Z. T., Schaefer, E. L., Roop, B. C., & Ally, A. H. (1987). Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster. Somat Cell Mol Genet, 13(6), 661–669. https://doi.org/10.1007/BF01534486
Wong, F., Z. T. Yuh, E. L. Schaefer, B. C. Roop, and A. H. Ally. “Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster.Somat Cell Mol Genet 13, no. 6 (November 1987): 661–69. https://doi.org/10.1007/BF01534486.
Wong F, Yuh ZT, Schaefer EL, Roop BC, Ally AH. Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster. Somat Cell Mol Genet. 1987 Nov;13(6):661–9.
Wong, F., et al. “Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster.Somat Cell Mol Genet, vol. 13, no. 6, Nov. 1987, pp. 661–69. Pubmed, doi:10.1007/BF01534486.
Wong F, Yuh ZT, Schaefer EL, Roop BC, Ally AH. Overlapping transcription units in the transient receptor potential locus of Drosophila melanogaster. Somat Cell Mol Genet. 1987 Nov;13(6):661–669.

Published In

Somat Cell Mol Genet

DOI

ISSN

0740-7750

Publication Date

November 1987

Volume

13

Issue

6

Start / End Page

661 / 669

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • RNA, Messenger
  • Photoreceptor Cells
  • Molecular Sequence Data
  • Genes
  • Drosophila melanogaster
  • Developmental Biology
  • DNA
  • Chromosome Mapping
  • Base Sequence