Rapid evolution of cis-regulatory sequences via local point mutations.
Publication
, Journal Article
Stone, JR; Wray, GA
Published in: Molecular biology and evolution
September 2001
Although the evolution of protein-coding sequences within genomes is well understood, the same cannot be said of the cis-regulatory regions that control transcription. Yet, changes in gene expression are likely to constitute an important component of phenotypic evolution. We simulated the evolution of new transcription factor binding sites via local point mutations. The results indicate that new binding sites appear and become fixed within populations on microevolutionary timescales under an assumption of neutral evolution. Even combinations of two new binding sites evolve very quickly. We predict that local point mutations continually generate considerable genetic variation that is capable of altering gene expression.
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Published In
Molecular biology and evolution
DOI
EISSN
1537-1719
ISSN
0737-4038
Publication Date
September 2001
Volume
18
Issue
9
Start / End Page
1764 / 1770
Related Subject Headings
- Transcription Factors
- Regulatory Sequences, Nucleic Acid
- Point Mutation
- Humans
- Evolutionary Biology
- Evolution, Molecular
- Databases, Factual
- DNA
- Computer Simulation
- Binding Sites
Citation
APA
Chicago
ICMJE
MLA
NLM
Stone, J. R., & Wray, G. A. (2001). Rapid evolution of cis-regulatory sequences via local point mutations. Molecular Biology and Evolution, 18(9), 1764–1770. https://doi.org/10.1093/oxfordjournals.molbev.a003964
Stone, J. R., and G. A. Wray. “Rapid evolution of cis-regulatory sequences via local point mutations.” Molecular Biology and Evolution 18, no. 9 (September 2001): 1764–70. https://doi.org/10.1093/oxfordjournals.molbev.a003964.
Stone JR, Wray GA. Rapid evolution of cis-regulatory sequences via local point mutations. Molecular biology and evolution. 2001 Sep;18(9):1764–70.
Stone, J. R., and G. A. Wray. “Rapid evolution of cis-regulatory sequences via local point mutations.” Molecular Biology and Evolution, vol. 18, no. 9, Sept. 2001, pp. 1764–70. Epmc, doi:10.1093/oxfordjournals.molbev.a003964.
Stone JR, Wray GA. Rapid evolution of cis-regulatory sequences via local point mutations. Molecular biology and evolution. 2001 Sep;18(9):1764–1770.
Published In
Molecular biology and evolution
DOI
EISSN
1537-1719
ISSN
0737-4038
Publication Date
September 2001
Volume
18
Issue
9
Start / End Page
1764 / 1770
Related Subject Headings
- Transcription Factors
- Regulatory Sequences, Nucleic Acid
- Point Mutation
- Humans
- Evolutionary Biology
- Evolution, Molecular
- Databases, Factual
- DNA
- Computer Simulation
- Binding Sites