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An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization

Publication ,  Journal Article
Thongphiew, D; Chankong, V; Yin, FF; Wu, QJ
Published in: Journal of Industrial and Management Optimization
January 1, 2008

Radiation therapy (RT) is a non-invasive and highly ekective treatment option for Prostate cancer. The goal is to deliver the prescription dose to the tumor (prostate) while minimizing the damages to the surrounding healthy organs namely bladder, rectum, and femoral heads. One major drawback of the conventional RT is that organ positions and shapes vary from day to day and that the original plan that is based on pre-treatment CT images may no longer be appropriate for treatment in subsequent sessions. The usual remedy is to include some margins surrounding the target when planning the treatment. Though this image guided radiation therapy technique allows in-room correction and can eliminate patient setup errors, the uncertainty due to organ deformation still remains. Performing a plan re-optimization will take about 30 minutes which makes it impractical to perform an online correction. In this paper, we develop an Adaptive Radiation Therapy (ART) system for online adaptive IMRT planning to compensate for the internal motion during the course of the prostate cancer treatment. It allows the treatment plan to be quickly modified based on the anatomy-of-the-day.

Duke Scholars

Published In

Journal of Industrial and Management Optimization

DOI

EISSN

1553-166X

ISSN

1547-5816

Publication Date

January 1, 2008

Volume

4

Issue

3

Start / End Page

453 / 475

Related Subject Headings

  • Operations Research
  • 4901 Applied mathematics
  • 3505 Human resources and industrial relations
  • 0801 Artificial Intelligence and Image Processing
  • 0103 Numerical and Computational Mathematics
  • 0102 Applied Mathematics
 

Citation

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Thongphiew, D., Chankong, V., Yin, F. F., & Wu, Q. J. (2008). An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization. Journal of Industrial and Management Optimization, 4(3), 453–475. https://doi.org/10.3934/jimo.2008.4.453
Thongphiew, D., V. Chankong, F. F. Yin, and Q. J. Wu. “An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization.” Journal of Industrial and Management Optimization 4, no. 3 (January 1, 2008): 453–75. https://doi.org/10.3934/jimo.2008.4.453.
Thongphiew D, Chankong V, Yin FF, Wu QJ. An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization. Journal of Industrial and Management Optimization. 2008 Jan 1;4(3):453–75.
Thongphiew, D., et al. “An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization.” Journal of Industrial and Management Optimization, vol. 4, no. 3, Jan. 2008, pp. 453–75. Scopus, doi:10.3934/jimo.2008.4.453.
Thongphiew D, Chankong V, Yin FF, Wu QJ. An on-line adaptive radiation therapy system for intensity modulated radiation therapy: An application of multi-objective optimization. Journal of Industrial and Management Optimization. 2008 Jan 1;4(3):453–475.

Published In

Journal of Industrial and Management Optimization

DOI

EISSN

1553-166X

ISSN

1547-5816

Publication Date

January 1, 2008

Volume

4

Issue

3

Start / End Page

453 / 475

Related Subject Headings

  • Operations Research
  • 4901 Applied mathematics
  • 3505 Human resources and industrial relations
  • 0801 Artificial Intelligence and Image Processing
  • 0103 Numerical and Computational Mathematics
  • 0102 Applied Mathematics