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3-D deformation guided on-line modification of multi-leaf collimators for adaptive radiation therapy

Publication ,  Journal Article
Zhou, B; Xuan, J; Wu, Q; Wang, Y
Published in: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
July 28, 2008

Adaptive radiation therapy (ART) requires an on-line modification of the treatment plan to compensate for the motion of organs. In this paper, an improved multi-leaf collimator (MLC) deformation approach is proposed to accurately compensate for the organ motion between the planning and treatment scans for ART. Instead of using slice-by-slice 2-D deformation field as in the original MLC deformation method, 3-D deformation field is first recovered by a volumetric deformable registration method to guide the MLC modification. In order to minimize the toxicity on organ-at-risk (OAR), the deformation fields of the OAR and planning target volume (PTV) are jointly used to adjust the MLC sequence of the original plan. The proposed approach has been applied to the radiotherapy for prostate cancer. Preliminary experimental results have demonstrated that the proposed method outperformed the original MLC approach with much reduced toxicity on OAR while maintaining great radiation efficacy on PTV. © 2008 Springer-Verlag Berlin Heidelberg.

Duke Scholars

Published In

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

DOI

EISSN

1611-3349

ISSN

0302-9743

Publication Date

July 28, 2008

Volume

5112 LNCS

Start / End Page

798 / 806

Related Subject Headings

  • Artificial Intelligence & Image Processing
  • 46 Information and computing sciences
 

Citation

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Zhou, B., Xuan, J., Wu, Q., & Wang, Y. (2008). 3-D deformation guided on-line modification of multi-leaf collimators for adaptive radiation therapy. Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 5112 LNCS, 798–806. https://doi.org/10.1007/978-3-540-69812-8_79
Zhou, B., J. Xuan, Q. Wu, and Y. Wang. “3-D deformation guided on-line modification of multi-leaf collimators for adaptive radiation therapy.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 5112 LNCS (July 28, 2008): 798–806. https://doi.org/10.1007/978-3-540-69812-8_79.
Zhou B, Xuan J, Wu Q, Wang Y. 3-D deformation guided on-line modification of multi-leaf collimators for adaptive radiation therapy. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2008 Jul 28;5112 LNCS:798–806.
Zhou, B., et al. “3-D deformation guided on-line modification of multi-leaf collimators for adaptive radiation therapy.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 5112 LNCS, July 2008, pp. 798–806. Scopus, doi:10.1007/978-3-540-69812-8_79.
Zhou B, Xuan J, Wu Q, Wang Y. 3-D deformation guided on-line modification of multi-leaf collimators for adaptive radiation therapy. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2008 Jul 28;5112 LNCS:798–806.

Published In

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

DOI

EISSN

1611-3349

ISSN

0302-9743

Publication Date

July 28, 2008

Volume

5112 LNCS

Start / End Page

798 / 806

Related Subject Headings

  • Artificial Intelligence & Image Processing
  • 46 Information and computing sciences