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mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye.

Publication ,  Journal Article
McNeill, H; Yang, CH; Brodsky, M; Ungos, J; Simon, MA
Published in: Genes Dev
April 15, 1997

The Drosophila eye is composed of dorsal and ventral mirror-image fields of opposite chiral forms of ommatidia. The boundary between these fields is known as the equator. We describe a novel gene, mirror (mrr), which is expressed in the dorsal half of the eye and plays a key role in forming the equator. Ectopic equators can be generated by juxtaposing mrr expressing and nonexpressing cells, and the path of the normal equator can be altered by changing the domain of mrr expression. These observations suggest that mrr is a key component in defining the dorsal-ventral boundary of tissue polarity in the eye. In addition, loss of mrr function leads to embryonic lethality and segmental defects, and its expression pattern suggests that it may also act to define segmental borders. Mirror is a member of the class of homeoproteins defined by the human proto-oncogene PBX1. mrr is similar to the Iroquois genes ara and caup and is located adjacent to them in this recently described homeotic cluster.

Duke Scholars

Published In

Genes Dev

DOI

ISSN

0890-9369

Publication Date

April 15, 1997

Volume

11

Issue

8

Start / End Page

1073 / 1082

Location

United States

Related Subject Headings

  • Transcription Factors
  • Sequence Homology, Amino Acid
  • Sequence Analysis, DNA
  • RNA, Messenger
  • Proto-Oncogene Proteins
  • Proto-Oncogene Mas
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Photoreceptor Cells, Invertebrate
  • Mutation
  • Molecular Sequence Data
 

Citation

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McNeill, H., Yang, C. H., Brodsky, M., Ungos, J., & Simon, M. A. (1997). mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. Genes Dev, 11(8), 1073–1082. https://doi.org/10.1101/gad.11.8.1073
McNeill, H., C. H. Yang, M. Brodsky, J. Ungos, and M. A. Simon. “mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye.Genes Dev 11, no. 8 (April 15, 1997): 1073–82. https://doi.org/10.1101/gad.11.8.1073.
McNeill H, Yang CH, Brodsky M, Ungos J, Simon MA. mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. Genes Dev. 1997 Apr 15;11(8):1073–82.
McNeill, H., et al. “mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye.Genes Dev, vol. 11, no. 8, Apr. 1997, pp. 1073–82. Pubmed, doi:10.1101/gad.11.8.1073.
McNeill H, Yang CH, Brodsky M, Ungos J, Simon MA. mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. Genes Dev. 1997 Apr 15;11(8):1073–1082.

Published In

Genes Dev

DOI

ISSN

0890-9369

Publication Date

April 15, 1997

Volume

11

Issue

8

Start / End Page

1073 / 1082

Location

United States

Related Subject Headings

  • Transcription Factors
  • Sequence Homology, Amino Acid
  • Sequence Analysis, DNA
  • RNA, Messenger
  • Proto-Oncogene Proteins
  • Proto-Oncogene Mas
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Photoreceptor Cells, Invertebrate
  • Mutation
  • Molecular Sequence Data