A model of accelerated aging induced by 5-bromodeoxyuridine.
Publication
, Journal Article
Butov, AA; Volkov, MA; Anisimov, VN; Sehl, ME; Yashin, AI
Published in: Biogerontology
January 2002
We consider a scheme of aging with two possible mechanisms of senescence processes: aging with apoptosis and necrosis for differentiated cells and a multistage process of malignant transformation. Our model describes the multistage phenomena of aging and carcinogenesis by a set of stochastic equations using multivariate and diffusion processes. This model fits experimental data on the acceleration of aging processes from postnatal exposure to 5-bromodeoxyuridine (BrdU), and the induction of genome instability. The methods of stochastic modeling and computer simulation of the processes of aging and carcinogenesis have been used for the verification of the biological suggestions.
Duke Scholars
Published In
Biogerontology
DOI
EISSN
1573-6768
ISSN
1389-5729
Publication Date
January 2002
Volume
3
Issue
3
Start / End Page
175 / 182
Related Subject Headings
- Stochastic Processes
- Rats
- Models, Biological
- Gerontology
- Computer Simulation
- Bromodeoxyuridine
- Animals
- Aging
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Butov, A. A., Volkov, M. A., Anisimov, V. N., Sehl, M. E., & Yashin, A. I. (2002). A model of accelerated aging induced by 5-bromodeoxyuridine. Biogerontology, 3(3), 175–182. https://doi.org/10.1023/a:1015647225196
Butov, Alexander A., Maxim A. Volkov, Vladimir N. Anisimov, Mary E. Sehl, and Anatoli I. Yashin. “A model of accelerated aging induced by 5-bromodeoxyuridine.” Biogerontology 3, no. 3 (January 2002): 175–82. https://doi.org/10.1023/a:1015647225196.
Butov AA, Volkov MA, Anisimov VN, Sehl ME, Yashin AI. A model of accelerated aging induced by 5-bromodeoxyuridine. Biogerontology. 2002 Jan;3(3):175–82.
Butov, Alexander A., et al. “A model of accelerated aging induced by 5-bromodeoxyuridine.” Biogerontology, vol. 3, no. 3, Jan. 2002, pp. 175–82. Epmc, doi:10.1023/a:1015647225196.
Butov AA, Volkov MA, Anisimov VN, Sehl ME, Yashin AI. A model of accelerated aging induced by 5-bromodeoxyuridine. Biogerontology. 2002 Jan;3(3):175–182.
Published In
Biogerontology
DOI
EISSN
1573-6768
ISSN
1389-5729
Publication Date
January 2002
Volume
3
Issue
3
Start / End Page
175 / 182
Related Subject Headings
- Stochastic Processes
- Rats
- Models, Biological
- Gerontology
- Computer Simulation
- Bromodeoxyuridine
- Animals
- Aging
- 3202 Clinical sciences
- 1103 Clinical Sciences