Multivariate frailty model with a major gene: Application to genealogical data
Publication
, Journal Article
Begun, A; Desjardins, B; Iachine, I; Yashin, A
Published in: Studies in Health Technology and Informatics
January 1, 2000
Multivariate survival models are shown to be appropriate for the analysis of the genetic and the environmental nature of a human life-span. Models which involve continuously distributed individual frailty, play an important role in the genetic analysis of an individual's susceptibility to disease and death. These models, however, are not appropriate for the detection of the effects of separate genes on survival. For this purpose we developed a 'major gene' frailty model of multivariate survival and applied it to simulated and real pedigree data. The analysis shows that this model can be used for the detection of the presence of major genes in the population and for the evaluation of the effects of such genes on survival.
Duke Scholars
Published In
Studies in Health Technology and Informatics
DOI
EISSN
1879-8365
ISSN
0926-9630
Publication Date
January 1, 2000
Volume
77
Start / End Page
412 / 416
Related Subject Headings
- Medical Informatics
- 1117 Public Health and Health Services
- 0807 Library and Information Studies
Citation
APA
Chicago
ICMJE
MLA
NLM
Begun, A., Desjardins, B., Iachine, I., & Yashin, A. (2000). Multivariate frailty model with a major gene: Application to genealogical data. Studies in Health Technology and Informatics, 77, 412–416. https://doi.org/10.3233/978-1-60750-921-9-412
Begun, A., B. Desjardins, I. Iachine, and A. Yashin. “Multivariate frailty model with a major gene: Application to genealogical data.” Studies in Health Technology and Informatics 77 (January 1, 2000): 412–16. https://doi.org/10.3233/978-1-60750-921-9-412.
Begun A, Desjardins B, Iachine I, Yashin A. Multivariate frailty model with a major gene: Application to genealogical data. Studies in Health Technology and Informatics. 2000 Jan 1;77:412–6.
Begun, A., et al. “Multivariate frailty model with a major gene: Application to genealogical data.” Studies in Health Technology and Informatics, vol. 77, Jan. 2000, pp. 412–16. Scopus, doi:10.3233/978-1-60750-921-9-412.
Begun A, Desjardins B, Iachine I, Yashin A. Multivariate frailty model with a major gene: Application to genealogical data. Studies in Health Technology and Informatics. 2000 Jan 1;77:412–416.
Published In
Studies in Health Technology and Informatics
DOI
EISSN
1879-8365
ISSN
0926-9630
Publication Date
January 1, 2000
Volume
77
Start / End Page
412 / 416
Related Subject Headings
- Medical Informatics
- 1117 Public Health and Health Services
- 0807 Library and Information Studies