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Expression and hormonal regulation of coactivator and corepressor genes.

Publication ,  Journal Article
Misiti, S; Schomburg, L; Yen, PM; Chin, WW
Published in: Endocrinology
May 1998

Steroid/thyroid/retinoid receptors are members of the nuclear receptor superfamily and ligand-inducible transcription factors. These receptors modulate transcription of various cellular genes, either positively or negatively, by interacting with specific hormone-response elements located in the target gene promoters. Recent data show that nuclear receptors enhance or inhibit transcription by recruiting an array of coactivator and corepressor proteins to the transcription complex. We examined and compared the expression of four coactivator (steroid receptor coactivator-1 and E1A-associated 300-kDa protein) and corepressor (SMRT and N-CoR) genes in a number of tissues including several endocrine glands and cell lines. We also addressed whether their messenger RNA levels are hormonally regulated by studying the effects of thyroid hormone (T3) and estrogen (E2) treatment in rat pituitary cells (GH3) in vitro and in anterior pituitary in vivo. Our studies show that there are distinct tissue-specific expression patterns of these genes. We show that T3 and E2 regulate the expression of steroid receptor coactivator-1 messenger RNA in the anterior pituitary in addition to a gender-related difference. These tissue variations may have physiological implications for heterogeneity of hormone responses that are observed in normal and malignant tissues.

Duke Scholars

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

May 1998

Volume

139

Issue

5

Start / End Page

2493 / 2500

Location

United States

Related Subject Headings

  • Triiodothyronine
  • Transcription Factors
  • Trans-Activators
  • Sex Characteristics
  • Repressor Proteins
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Pituitary Gland
  • Nuclear Receptor Coactivator 1
 

Citation

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Misiti, S., Schomburg, L., Yen, P. M., & Chin, W. W. (1998). Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology, 139(5), 2493–2500. https://doi.org/10.1210/endo.139.5.5971
Misiti, S., L. Schomburg, P. M. Yen, and W. W. Chin. “Expression and hormonal regulation of coactivator and corepressor genes.Endocrinology 139, no. 5 (May 1998): 2493–2500. https://doi.org/10.1210/endo.139.5.5971.
Misiti S, Schomburg L, Yen PM, Chin WW. Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology. 1998 May;139(5):2493–500.
Misiti, S., et al. “Expression and hormonal regulation of coactivator and corepressor genes.Endocrinology, vol. 139, no. 5, May 1998, pp. 2493–500. Pubmed, doi:10.1210/endo.139.5.5971.
Misiti S, Schomburg L, Yen PM, Chin WW. Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology. 1998 May;139(5):2493–2500.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

May 1998

Volume

139

Issue

5

Start / End Page

2493 / 2500

Location

United States

Related Subject Headings

  • Triiodothyronine
  • Transcription Factors
  • Trans-Activators
  • Sex Characteristics
  • Repressor Proteins
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Pituitary Gland
  • Nuclear Receptor Coactivator 1