A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
Publication
, Journal Article
York, JD; Odom, AR; Murphy, R; Ives, EB; Wente, SR
Published in: Science
July 2, 1999
In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4, 5-bisphosphate to inositol hexakisphosphate (IP6). The common downstream effects of mutations in each component were deficiencies in IP6 synthesis and messenger RNA export, indicating a role for IP6 in GLE1 function and messenger RNA export.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
July 2, 1999
Volume
285
Issue
5424
Start / End Page
96 / 100
Location
United States
Related Subject Headings
- Type C Phospholipases
- Signal Transduction
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- RNA, Messenger
- RNA, Fungal
- Phytic Acid
- Phosphotransferases (Alcohol Group Acceptor)
- Nuclear Pore Complex Proteins
- Nuclear Envelope
Citation
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York, J. D., Odom, A. R., Murphy, R., Ives, E. B., & Wente, S. R. (1999). A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science, 285(5424), 96–100. https://doi.org/10.1126/science.285.5424.96
York, J. D., A. R. Odom, R. Murphy, E. B. Ives, and S. R. Wente. “A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.” Science 285, no. 5424 (July 2, 1999): 96–100. https://doi.org/10.1126/science.285.5424.96.
York JD, Odom AR, Murphy R, Ives EB, Wente SR. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science. 1999 Jul 2;285(5424):96–100.
York, J. D., et al. “A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.” Science, vol. 285, no. 5424, July 1999, pp. 96–100. Pubmed, doi:10.1126/science.285.5424.96.
York JD, Odom AR, Murphy R, Ives EB, Wente SR. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science. 1999 Jul 2;285(5424):96–100.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
July 2, 1999
Volume
285
Issue
5424
Start / End Page
96 / 100
Location
United States
Related Subject Headings
- Type C Phospholipases
- Signal Transduction
- Saccharomyces cerevisiae Proteins
- Saccharomyces cerevisiae
- RNA, Messenger
- RNA, Fungal
- Phytic Acid
- Phosphotransferases (Alcohol Group Acceptor)
- Nuclear Pore Complex Proteins
- Nuclear Envelope