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Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.

Publication ,  Journal Article
Poltoratsky, VP; Shi, X; York, JD; Lieber, MR; Carter, TH
Published in: J Immunol
November 15, 1995

DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA-PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases.

Duke Scholars

Published In

J Immunol

ISSN

0022-1767

Publication Date

November 15, 1995

Volume

155

Issue

10

Start / End Page

4529 / 4533

Location

United States

Related Subject Headings

  • Sequence Homology, Amino Acid
  • Sequence Analysis
  • Protein Serine-Threonine Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • Nuclear Proteins
  • Molecular Sequence Data
  • Immunology
  • Humans
  • DNA-Binding Proteins
  • DNA-Activated Protein Kinase
 

Citation

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Poltoratsky, V. P., Shi, X., York, J. D., Lieber, M. R., & Carter, T. H. (1995). Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol, 155(10), 4529–4533.
Poltoratsky, V. P., X. Shi, J. D. York, M. R. Lieber, and T. H. Carter. “Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.J Immunol 155, no. 10 (November 15, 1995): 4529–33.
Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol. 1995 Nov 15;155(10):4529–33.
Poltoratsky, V. P., et al. “Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.J Immunol, vol. 155, no. 10, Nov. 1995, pp. 4529–33.
Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol. 1995 Nov 15;155(10):4529–4533.

Published In

J Immunol

ISSN

0022-1767

Publication Date

November 15, 1995

Volume

155

Issue

10

Start / End Page

4529 / 4533

Location

United States

Related Subject Headings

  • Sequence Homology, Amino Acid
  • Sequence Analysis
  • Protein Serine-Threonine Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • Nuclear Proteins
  • Molecular Sequence Data
  • Immunology
  • Humans
  • DNA-Binding Proteins
  • DNA-Activated Protein Kinase