Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.
Publication
, Journal Article
Poltoratsky, VP; Shi, X; York, JD; Lieber, MR; Carter, TH
Published in: J Immunol
November 15, 1995
DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA-PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases.
Duke Scholars
Published In
J Immunol
ISSN
0022-1767
Publication Date
November 15, 1995
Volume
155
Issue
10
Start / End Page
4529 / 4533
Location
United States
Related Subject Headings
- Sequence Homology, Amino Acid
- Sequence Analysis
- Protein Serine-Threonine Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Nuclear Proteins
- Molecular Sequence Data
- Immunology
- Humans
- DNA-Binding Proteins
- DNA-Activated Protein Kinase
Citation
APA
Chicago
ICMJE
MLA
NLM
Poltoratsky, V. P., Shi, X., York, J. D., Lieber, M. R., & Carter, T. H. (1995). Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol, 155(10), 4529–4533.
Poltoratsky, V. P., X. Shi, J. D. York, M. R. Lieber, and T. H. Carter. “Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.” J Immunol 155, no. 10 (November 15, 1995): 4529–33.
Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol. 1995 Nov 15;155(10):4529–33.
Poltoratsky, V. P., et al. “Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.” J Immunol, vol. 155, no. 10, Nov. 1995, pp. 4529–33.
Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol. 1995 Nov 15;155(10):4529–4533.
Published In
J Immunol
ISSN
0022-1767
Publication Date
November 15, 1995
Volume
155
Issue
10
Start / End Page
4529 / 4533
Location
United States
Related Subject Headings
- Sequence Homology, Amino Acid
- Sequence Analysis
- Protein Serine-Threonine Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Nuclear Proteins
- Molecular Sequence Data
- Immunology
- Humans
- DNA-Binding Proteins
- DNA-Activated Protein Kinase