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Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study.

Publication ,  Journal Article
Gorse, GJ; O'Connor, TZ; Young, SL; Mendelman, PM; Bradley, SF; Nichol, KL; Strickland, JH; Paulson, DM; Rice, KL; Foster, RA; Fulambarker, AM ...
Published in: Vaccine
May 16, 2003

We assessed whether trivalent live, cold-adapted influenza virus (CAIV-T) vaccine provides added protection when co-administered with trivalent inactivated influenza virus vaccine (TVV) in patients with chronic obstructive pulmonary disease (COPD). Subjects (N=2215) were randomly assigned to receive either TVV intramuscularly (IM) and CAIV-T intranasally (TC), or TVV and placebo (TP). The vaccines were well-tolerated. Efficacy of TC compared to TP was not statistically significant and was 0.16 for any influenza virus strain (95% confidence limit (CL): -0.22, 0.43), 0.26 for A (H3N2) virus (95% CL: -0.17, 0.53), and -0.05 for type B virus (95% CL: -1.13, 0.48). However, there was a possible advantage for TC over TP in reducing respiratory consequences of an influenza season measured by pulmonary function and symptoms at end of study.

Duke Scholars

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

May 16, 2003

Volume

21

Issue

17-18

Start / End Page

2133 / 2144

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccines, Inactivated
  • United States
  • Reproducibility of Results
  • Pulmonary Disease, Chronic Obstructive
  • Placebos
  • Middle Aged
  • Injections, Intramuscular
  • Influenza, Human
  • Influenza Vaccines
 

Citation

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Gorse, G. J., O’Connor, T. Z., Young, S. L., Mendelman, P. M., Bradley, S. F., Nichol, K. L., … Peduzzi, P. N. (2003). Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study. Vaccine, 21(17–18), 2133–2144. https://doi.org/10.1016/s0264-410x(02)00748-x
Gorse, Geoffrey J., Theresa Z. O’Connor, Stephen L. Young, Paul M. Mendelman, Suzanne F. Bradley, Kristin L. Nichol, James H. Strickland, et al. “Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study.Vaccine 21, no. 17–18 (May 16, 2003): 2133–44. https://doi.org/10.1016/s0264-410x(02)00748-x.
Gorse GJ, O’Connor TZ, Young SL, Mendelman PM, Bradley SF, Nichol KL, et al. Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study. Vaccine. 2003 May 16;21(17–18):2133–44.
Gorse, Geoffrey J., et al. “Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study.Vaccine, vol. 21, no. 17–18, May 2003, pp. 2133–44. Pubmed, doi:10.1016/s0264-410x(02)00748-x.
Gorse GJ, O’Connor TZ, Young SL, Mendelman PM, Bradley SF, Nichol KL, Strickland JH, Paulson DM, Rice KL, Foster RA, Fulambarker AM, Shigeoka JW, Kuschner WG, Goodman RP, Neuzil KM, Wittes J, Boardman KD, Peduzzi PN. Efficacy trial of live, cold-adapted and inactivated influenza virus vaccines in older adults with chronic obstructive pulmonary disease: a VA cooperative study. Vaccine. 2003 May 16;21(17–18):2133–2144.
Journal cover image

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

May 16, 2003

Volume

21

Issue

17-18

Start / End Page

2133 / 2144

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccines, Inactivated
  • United States
  • Reproducibility of Results
  • Pulmonary Disease, Chronic Obstructive
  • Placebos
  • Middle Aged
  • Injections, Intramuscular
  • Influenza, Human
  • Influenza Vaccines