Skip to main content
Journal cover image

Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults.

Publication ,  Journal Article
Zeng, Y; Hughes, CL; Lewis, MA; Li, J; Zhang, F
Published in: J Gerontol A Biol Sci Med Sci
October 2011

Based on the multiple logistic regression analysis of data from a random sample of 1,023 old adults collected in Taiwan in 2000, we found that interactions between carrying the APOE4 allele and one of four life stress factors (relocated mainlander, living in a crowded household with six or more persons, living in an earthquake-damaged house, and monthly financial difficulty) significantly increased the odds ratio of poor self-reported health. Correlations between carrying the APOE4 allele and the life stress factors were ruled out by statistical tests. These life stress factors had a substantially larger adverse impact on self-reported health in APOE4 allele carriers than in noncarriers. This study provides evidence that interaction between carrying APOE4 allele and chronic life stressors has significant impacts on self-reported health while controlling for various sociodemographic and health behavior factors. Further studies with richer biomarkers are warranted for deeper understanding of the biological mechanisms.

Duke Scholars

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

October 2011

Volume

66

Issue

10

Start / End Page

1054 / 1061

Location

United States

Related Subject Headings

  • Taiwan
  • Stress, Psychological
  • Self Disclosure
  • Polymorphism, Restriction Fragment Length
  • Polymerase Chain Reaction
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Logistic Models
  • Interviews as Topic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zeng, Y., Hughes, C. L., Lewis, M. A., Li, J., & Zhang, F. (2011). Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults. J Gerontol A Biol Sci Med Sci, 66(10), 1054–1061. https://doi.org/10.1093/gerona/glr106
Zeng, Yi, Claude L. Hughes, Megan A. Lewis, Jianxin Li, and Fengyu Zhang. “Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults.J Gerontol A Biol Sci Med Sci 66, no. 10 (October 2011): 1054–61. https://doi.org/10.1093/gerona/glr106.
Zeng Y, Hughes CL, Lewis MA, Li J, Zhang F. Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults. J Gerontol A Biol Sci Med Sci. 2011 Oct;66(10):1054–61.
Zeng, Yi, et al. “Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults.J Gerontol A Biol Sci Med Sci, vol. 66, no. 10, Oct. 2011, pp. 1054–61. Pubmed, doi:10.1093/gerona/glr106.
Zeng Y, Hughes CL, Lewis MA, Li J, Zhang F. Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults. J Gerontol A Biol Sci Med Sci. 2011 Oct;66(10):1054–1061.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

October 2011

Volume

66

Issue

10

Start / End Page

1054 / 1061

Location

United States

Related Subject Headings

  • Taiwan
  • Stress, Psychological
  • Self Disclosure
  • Polymorphism, Restriction Fragment Length
  • Polymerase Chain Reaction
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Logistic Models
  • Interviews as Topic