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The role and regulation of mTOR in T-lymphocyte function.

Publication ,  Journal Article
O'Brien, TF; Zhong, X-P
Published in: Arch Immunol Ther Exp (Warsz)
June 2012

The conversion of naïve T cells into effector T cells is initiated by stimulation through the T-cell receptor (TCR). Upon activation, T cells undergo significant morphological and functional changes, putting new metabolic demands on the cell. Past research has identified the mammalian target of rapamycin (mTOR) as a critical regulator of cell metabolism, and the development of new genetic models has begun to reveal an important role for this pathway in the homeostasis and function of T lymphocytes. In this review, we focus on the most recent findings that demonstrate the ability of mTOR to regulate T-cell activation, CD8(+) memory cell formation and function, and helper T lineage differentiation. Furthermore, we highlight the importance of tight control of mTOR signaling by tuberous sclerosis complex 1 for T-cell homeostasis, and the regulation of mTOR signaling by diacylglycerol kinases and the RasGRP1-Ras-Erk1/2 pathway in the context of TCR signaling.

Duke Scholars

Published In

Arch Immunol Ther Exp (Warsz)

DOI

EISSN

1661-4917

Publication Date

June 2012

Volume

60

Issue

3

Start / End Page

173 / 181

Location

Switzerland

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tuberous Sclerosis Complex 1 Protein
  • TOR Serine-Threonine Kinases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Antigen, T-Cell
  • Mice
  • MAP Kinase Signaling System
  • Lymphocyte Activation
  • Immunology
 

Citation

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ICMJE
MLA
NLM
O’Brien, T. F., & Zhong, X.-P. (2012). The role and regulation of mTOR in T-lymphocyte function. Arch Immunol Ther Exp (Warsz), 60(3), 173–181. https://doi.org/10.1007/s00005-012-0171-4
O’Brien, Thomas F., and Xiao-Ping Zhong. “The role and regulation of mTOR in T-lymphocyte function.Arch Immunol Ther Exp (Warsz) 60, no. 3 (June 2012): 173–81. https://doi.org/10.1007/s00005-012-0171-4.
O’Brien TF, Zhong X-P. The role and regulation of mTOR in T-lymphocyte function. Arch Immunol Ther Exp (Warsz). 2012 Jun;60(3):173–81.
O’Brien, Thomas F., and Xiao-Ping Zhong. “The role and regulation of mTOR in T-lymphocyte function.Arch Immunol Ther Exp (Warsz), vol. 60, no. 3, June 2012, pp. 173–81. Pubmed, doi:10.1007/s00005-012-0171-4.
O’Brien TF, Zhong X-P. The role and regulation of mTOR in T-lymphocyte function. Arch Immunol Ther Exp (Warsz). 2012 Jun;60(3):173–181.
Journal cover image

Published In

Arch Immunol Ther Exp (Warsz)

DOI

EISSN

1661-4917

Publication Date

June 2012

Volume

60

Issue

3

Start / End Page

173 / 181

Location

Switzerland

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tuberous Sclerosis Complex 1 Protein
  • TOR Serine-Threonine Kinases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Antigen, T-Cell
  • Mice
  • MAP Kinase Signaling System
  • Lymphocyte Activation
  • Immunology