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Receptor signaling in immune cell development and function.

Publication ,  Journal Article
Zhong, X-P; Shin, J; Gorentla, BK; O'Brien, T; Srivatsan, S; Xu, L; Chen, Y; Xie, D; Pan, H
Published in: Immunol Res
April 2011

Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE transduces signal that promotes mast cell survival and induces mast cell activation. In dendritic cells and macrophages, the toll-like receptors recognize microbial pathogens and play critical roles for both innate and adaptive immunity against pathogens. Our research explores how signaling from these receptors is transduced and regulated to better understand these immune cells. Our recent studies have revealed diacylglycerol kinases and TSC1/2-mTOR as critical signaling molecules/regulators in T cells, mast cells, dendritic cells, and macrophages.

Duke Scholars

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

109 / 123

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tuberous Sclerosis Complex 2 Protein
  • Tuberous Sclerosis Complex 1 Protein
  • Toll-Like Receptors
  • TOR Serine-Threonine Kinases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Antigen, T-Cell
  • Mice
  • Mast Cells
 

Citation

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MLA
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Zhong, X.-P., Shin, J., Gorentla, B. K., O’Brien, T., Srivatsan, S., Xu, L., … Pan, H. (2011). Receptor signaling in immune cell development and function. Immunol Res, 49(1–3), 109–123. https://doi.org/10.1007/s12026-010-8175-9
Zhong, Xiao-Ping, Jinwook Shin, Balachandra K. Gorentla, Tommy O’Brien, Sruti Srivatsan, Li Xu, Yong Chen, Danli Xie, and Hongjie Pan. “Receptor signaling in immune cell development and function.Immunol Res 49, no. 1–3 (April 2011): 109–23. https://doi.org/10.1007/s12026-010-8175-9.
Zhong X-P, Shin J, Gorentla BK, O’Brien T, Srivatsan S, Xu L, et al. Receptor signaling in immune cell development and function. Immunol Res. 2011 Apr;49(1–3):109–23.
Zhong, Xiao-Ping, et al. “Receptor signaling in immune cell development and function.Immunol Res, vol. 49, no. 1–3, Apr. 2011, pp. 109–23. Pubmed, doi:10.1007/s12026-010-8175-9.
Zhong X-P, Shin J, Gorentla BK, O’Brien T, Srivatsan S, Xu L, Chen Y, Xie D, Pan H. Receptor signaling in immune cell development and function. Immunol Res. 2011 Apr;49(1–3):109–123.
Journal cover image

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

109 / 123

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tuberous Sclerosis Complex 2 Protein
  • Tuberous Sclerosis Complex 1 Protein
  • Toll-Like Receptors
  • TOR Serine-Threonine Kinases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Antigen, T-Cell
  • Mice
  • Mast Cells