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Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.

Publication ,  Journal Article
Zhong, X-P; Hainey, EA; Olenchock, BA; Jordan, MS; Maltzman, JS; Nichols, KE; Shen, H; Koretzky, GA
Published in: Nat Immunol
September 2003

Much is known about how T cell receptor (TCR) engagement leads to T cell activation; however, the mechanisms terminating TCR signaling remain less clear. Diacylglycerol, generated after TCR ligation, is essential in T cells. Its function must be controlled tightly to maintain normal T cell homeostasis. Previous studies have shown that diacylglycerol kinase zeta (DGKzeta), which converts diacylglycerol to phosphatidic acid, can inhibit TCR signaling. Here we show that DGKzeta-deficient T cells are hyperresponsive to TCR stimulation both ex vivo and in vivo. Furthermore, DGKzeta-deficient mice mounted a more robust immune response to lymphocytic choriomeningitis virus infection than did wild-type mice. These results demonstrate the importance of DGKzeta as a physiological negative regulator of TCR signaling and T cell activation.

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Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

September 2003

Volume

4

Issue

9

Start / End Page

882 / 890

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Interleukin-2
  • Receptors, Antigen, T-Cell
  • Phosphatidic Acids
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocytic Choriomeningitis
  • Lymphocyte Activation
 

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Zhong, X.-P., Hainey, E. A., Olenchock, B. A., Jordan, M. S., Maltzman, J. S., Nichols, K. E., … Koretzky, G. A. (2003). Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat Immunol, 4(9), 882–890. https://doi.org/10.1038/ni958
Zhong, Xiao-Ping, Ehmonie A. Hainey, Benjamin A. Olenchock, Martha S. Jordan, Jonathan S. Maltzman, Kim E. Nichols, Hao Shen, and Gary A. Koretzky. “Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.Nat Immunol 4, no. 9 (September 2003): 882–90. https://doi.org/10.1038/ni958.
Zhong X-P, Hainey EA, Olenchock BA, Jordan MS, Maltzman JS, Nichols KE, et al. Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat Immunol. 2003 Sep;4(9):882–90.
Zhong, Xiao-Ping, et al. “Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.Nat Immunol, vol. 4, no. 9, Sept. 2003, pp. 882–90. Pubmed, doi:10.1038/ni958.
Zhong X-P, Hainey EA, Olenchock BA, Jordan MS, Maltzman JS, Nichols KE, Shen H, Koretzky GA. Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat Immunol. 2003 Sep;4(9):882–890.

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

September 2003

Volume

4

Issue

9

Start / End Page

882 / 890

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Interleukin-2
  • Receptors, Antigen, T-Cell
  • Phosphatidic Acids
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocytic Choriomeningitis
  • Lymphocyte Activation