Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.
Publication
, Journal Article
Melancon, K; Cheng, Q; Kiefer, TL; Dai, J; Lai, L; Dong, C; Yuan, L; Collins, A; Thiyagarajah, A; Long, S; Hill, SM
Published in: Cancer Lett
September 8, 2005
A significant increase in tumor regression was induced in N-nitroso-N-methylurea-induced mammary tumors in rats treated with the combination of melatonin and 9-cis-retinoic acid (9cRA). Treatment groups included: control (ethanolic saline), 9cRA (30 mg/kg chow/day), melatonin 500 microg/day, melatonin 1000 microg/day, melatonin 500 microg/day+9cRA and melatonin 1000 microg/day+9cRA. Rats treated with the lower dose of melatonin 500 microg+9cRA show the greatest degree of tumor regression (78%), with 54% undergoing complete regression and a significant increase in apoptotic cells observed by TUNEL Assay. Furthermore, tumor multiplicity and burden were significantly decreased by the combination of melatonin and 9cRA.
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Published In
Cancer Lett
DOI
ISSN
0304-3835
Publication Date
September 8, 2005
Volume
227
Issue
1
Start / End Page
39 / 48
Location
Ireland
Related Subject Headings
- Tretinoin
- Rats, Sprague-Dawley
- Rats
- RNA, Messenger
- Oncology & Carcinogenesis
- Methylnitrosourea
- Melatonin
- Mammary Neoplasms, Experimental
- Female
- Estrogen Receptor alpha
Citation
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ICMJE
MLA
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Melancon, K., Cheng, Q., Kiefer, T. L., Dai, J., Lai, L., Dong, C., … Hill, S. M. (2005). Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid. Cancer Lett, 227(1), 39–48. https://doi.org/10.1016/j.canlet.2005.01.005
Melancon, K., Q. Cheng, T. L. Kiefer, J. Dai, L. Lai, C. Dong, L. Yuan, et al. “Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.” Cancer Lett 227, no. 1 (September 8, 2005): 39–48. https://doi.org/10.1016/j.canlet.2005.01.005.
Melancon K, Cheng Q, Kiefer TL, Dai J, Lai L, Dong C, et al. Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid. Cancer Lett. 2005 Sep 8;227(1):39–48.
Melancon, K., et al. “Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.” Cancer Lett, vol. 227, no. 1, Sept. 2005, pp. 39–48. Pubmed, doi:10.1016/j.canlet.2005.01.005.
Melancon K, Cheng Q, Kiefer TL, Dai J, Lai L, Dong C, Yuan L, Collins A, Thiyagarajah A, Long S, Hill SM. Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid. Cancer Lett. 2005 Sep 8;227(1):39–48.
Published In
Cancer Lett
DOI
ISSN
0304-3835
Publication Date
September 8, 2005
Volume
227
Issue
1
Start / End Page
39 / 48
Location
Ireland
Related Subject Headings
- Tretinoin
- Rats, Sprague-Dawley
- Rats
- RNA, Messenger
- Oncology & Carcinogenesis
- Methylnitrosourea
- Melatonin
- Mammary Neoplasms, Experimental
- Female
- Estrogen Receptor alpha