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Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results.

Publication ,  Journal Article
Queenan, JT; Veeck, LL; Seltman, HJ; Muasher, SJ
Published in: Fertil Steril
September 1994

OBJECTIVE: To examine the results of 7 years of thawed ET during natural or controlled cycles using exogenous steroids. DESIGN: Retrospective evaluation to compare implantation and pregnancy rates with two protocols for transfer of cryopreserved-thawed pre-embryos. SETTING: Tertiary care academic center. PATIENTS: From January 1987 to December 1993, 521 patients who were < 40 years of age underwent 628 thawed embryo transfers. MAIN OUTCOME MEASURE: Pregnancy and implantation rates per thawed embryo transfer cycle. RESULTS: A total 1,987 pre-embryos survived the thawing process and were used in 628 thaw-transfer cycles. Transfer was performed in a natural cycle 2 days after the LH peak or on day 17 of a programmed cycle using a GnRH-agonist and hormone replacement therapy protocol; 182 pregnancies were established (182/628; 29%). Similar pregnancy rates were seen in the natural cycle (112/398; 28%) and the programmed cycle (70/230; 30%). The implantation rates were similar in the two methods of transfer cycles (11.9% versus 10.3%, natural versus programmed cycle). There were no significant differences in clinical or ongoing pregnancy rates in a natural or programmed cycle, correcting for the number of cryopreserved-thawed pre-embryos transferred. Patient's age at the time of freezing and the number of cryopreserved-thawed pre-embryos transferred are more important determinants of pregnancy than the type of cycle in which transfer occurs. CONCLUSION: Transferring cryopreserved-thawed pre-embryos in a natural or programmed cycle yields similar pregnancy results.

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Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

September 1994

Volume

62

Issue

3

Start / End Page

545 / 550

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Regression Analysis
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Menstrual Cycle
  • Humans
  • Hormones
  • Female
  • Embryo Transfer
  • Embryo Implantation
 

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Queenan, J. T., Veeck, L. L., Seltman, H. J., & Muasher, S. J. (1994). Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results. Fertil Steril, 62(3), 545–550. https://doi.org/10.1016/s0015-0282(16)56943-x
Queenan, J. T., L. L. Veeck, H. J. Seltman, and S. J. Muasher. “Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results.Fertil Steril 62, no. 3 (September 1994): 545–50. https://doi.org/10.1016/s0015-0282(16)56943-x.
Queenan, J. T., et al. “Transfer of cryopreserved-thawed pre-embryos in a natural cycle or a programmed cycle with exogenous hormonal replacement yields similar pregnancy results.Fertil Steril, vol. 62, no. 3, Sept. 1994, pp. 545–50. Pubmed, doi:10.1016/s0015-0282(16)56943-x.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

September 1994

Volume

62

Issue

3

Start / End Page

545 / 550

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Regression Analysis
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Menstrual Cycle
  • Humans
  • Hormones
  • Female
  • Embryo Transfer
  • Embryo Implantation