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The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle.

Publication ,  Journal Article
Winslow, KL; Toner, JP; Brzyski, RG; Oehninger, SC; Acosta, AA; Muasher, SJ
Published in: Fertil Steril
October 1991

OBJECTIVE: To evaluate the initial versus early pattern of estradiol (E2) change after administration of a gonadotropin-releasing hormone agonist (GnRH-a), i.e., the GnRH-a stimulation test versus E2 pattern, respectively, as predictors of ovarian response and pregnancy in in vitro fertilization (IVF) patients stimulated with a flare-up protocol. DESIGN: Prospective study in a consecutive group of patients. SETTING: Tertiary care, institutional setting. PATIENTS: Two hundred twenty-eight patients entered and completed the study. The only patients excluded from study were those anticipated to have polycystic ovarian disease, those with a single ovary, or those with an ovarian cyst(s). INTERVENTIONS: Patients were stimulated with a GnRH-a flare-up protocol beginning on menstrual day 2. MAIN OUTCOME: Evaluation of the GnRH-a stimulation test and the E2 pattern as predictors of the number of mature oocytes retrieved and pregnancy. RESULTS: The GnRH-a stimulation test but not the E2 pattern was predictive of the number of mature oocytes retrieved (r = 0.53, P less than 1 X 10(-5) and pregnancy (chi 2 = 8.5, P = 0.04). The E2 pattern was predictive of the duration and number of ampules of gonadotropin required for stimulation. CONCLUSION: The GnRH-a stimulation test is a sensitive predictor of performance in the flare-up IVF cycle.

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Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

October 1991

Volume

56

Issue

4

Start / End Page

711 / 717

Location

United States

Related Subject Headings

  • Prospective Studies
  • Prognosis
  • Pregnancy
  • Ovary
  • Oocytes
  • Obstetrics & Reproductive Medicine
  • Menotropins
  • Leuprolide
  • Humans
  • Follicle Stimulating Hormone
 

Citation

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Winslow, K. L., Toner, J. P., Brzyski, R. G., Oehninger, S. C., Acosta, A. A., & Muasher, S. J. (1991). The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle. Fertil Steril, 56(4), 711–717. https://doi.org/10.1016/s0015-0282(16)54604-4
Winslow, K. L., J. P. Toner, R. G. Brzyski, S. C. Oehninger, A. A. Acosta, and S. J. Muasher. “The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle.Fertil Steril 56, no. 4 (October 1991): 711–17. https://doi.org/10.1016/s0015-0282(16)54604-4.
Winslow KL, Toner JP, Brzyski RG, Oehninger SC, Acosta AA, Muasher SJ. The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle. Fertil Steril. 1991 Oct;56(4):711–7.
Winslow, K. L., et al. “The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle.Fertil Steril, vol. 56, no. 4, Oct. 1991, pp. 711–17. Pubmed, doi:10.1016/s0015-0282(16)54604-4.
Winslow KL, Toner JP, Brzyski RG, Oehninger SC, Acosta AA, Muasher SJ. The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle. Fertil Steril. 1991 Oct;56(4):711–717.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

October 1991

Volume

56

Issue

4

Start / End Page

711 / 717

Location

United States

Related Subject Headings

  • Prospective Studies
  • Prognosis
  • Pregnancy
  • Ovary
  • Oocytes
  • Obstetrics & Reproductive Medicine
  • Menotropins
  • Leuprolide
  • Humans
  • Follicle Stimulating Hormone