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Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome.

Publication ,  Journal Article
Edelstein, MC; Seltman, HJ; Cox, BJ; Robinson, SM; Shaw, RA; Muasher, SJ
Published in: Fertil Steril
November 1990

In in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone agonist (GnRH-a) suppression, we investigated whether an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration indicates premature luteinization and is associated with a lower pregnancy rate. We retrospectively studied 101 patients treated with the GnRH-a leuprolide acetate, begun in the luteal phase of the prior menstrual cycle and continued until the day of hCG administration. On the day of hCG, 72 patients had P less than 0.9 ng/mL and 29 had less than or equal to 0.9 ng/mL. Patients in the high P group had a significantly greater estradiol level on the day of hCG. No significant difference in clinical pregnancy rates or ongoing pregnancy rates occurred between the low P and high P groups. We conclude that in IVF cycles pretreated with GnRH-a, P levels on the day of hCG are not predictive of conceiving in that cycle.

Duke Scholars

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

November 1990

Volume

54

Issue

5

Start / End Page

853 / 857

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Progesterone
  • Pregnancy Outcome
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Luteinizing Hormone
  • Leuprolide
  • Injections, Subcutaneous
  • Humans
  • Gonadotropin-Releasing Hormone
 

Citation

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Edelstein, M. C., Seltman, H. J., Cox, B. J., Robinson, S. M., Shaw, R. A., & Muasher, S. J. (1990). Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome. Fertil Steril, 54(5), 853–857. https://doi.org/10.1016/s0015-0282(16)53945-4
Edelstein, M. C., H. J. Seltman, B. J. Cox, S. M. Robinson, R. A. Shaw, and S. J. Muasher. “Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome.Fertil Steril 54, no. 5 (November 1990): 853–57. https://doi.org/10.1016/s0015-0282(16)53945-4.
Edelstein, M. C., et al. “Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome.Fertil Steril, vol. 54, no. 5, Nov. 1990, pp. 853–57. Pubmed, doi:10.1016/s0015-0282(16)53945-4.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

November 1990

Volume

54

Issue

5

Start / End Page

853 / 857

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Progesterone
  • Pregnancy Outcome
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Luteinizing Hormone
  • Leuprolide
  • Injections, Subcutaneous
  • Humans
  • Gonadotropin-Releasing Hormone