Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome.
In in vitro fertilization (IVF) cycles using gonadotropin-releasing hormone agonist (GnRH-a) suppression, we investigated whether an elevated progesterone (P) level on the day of human chorionic gonadotropin (hCG) administration indicates premature luteinization and is associated with a lower pregnancy rate. We retrospectively studied 101 patients treated with the GnRH-a leuprolide acetate, begun in the luteal phase of the prior menstrual cycle and continued until the day of hCG administration. On the day of hCG, 72 patients had P less than 0.9 ng/mL and 29 had less than or equal to 0.9 ng/mL. Patients in the high P group had a significantly greater estradiol level on the day of hCG. No significant difference in clinical pregnancy rates or ongoing pregnancy rates occurred between the low P and high P groups. We conclude that in IVF cycles pretreated with GnRH-a, P levels on the day of hCG are not predictive of conceiving in that cycle.
Duke Scholars
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Related Subject Headings
- Retrospective Studies
- Progesterone
- Pregnancy Outcome
- Pregnancy
- Obstetrics & Reproductive Medicine
- Luteinizing Hormone
- Leuprolide
- Injections, Subcutaneous
- Humans
- Gonadotropin-Releasing Hormone
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Retrospective Studies
- Progesterone
- Pregnancy Outcome
- Pregnancy
- Obstetrics & Reproductive Medicine
- Luteinizing Hormone
- Leuprolide
- Injections, Subcutaneous
- Humans
- Gonadotropin-Releasing Hormone