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Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program.

Publication ,  Journal Article
Acosta, AA; Oehninger, S; Hammer, J; Muasher, SJ; Liang, HM; Jones, DL
Published in: Fertil Steril
April 1990

Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum beta-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.

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Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

April 1990

Volume

53

Issue

4

Start / End Page

673 / 676

Location

United States

Related Subject Headings

  • Prognosis
  • Progesterone
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Norway
  • Menstrual Cycle
  • Humans
  • Fertilization in Vitro
  • Female
  • Estradiol
 

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Acosta, A. A., Oehninger, S., Hammer, J., Muasher, S. J., Liang, H. M., & Jones, D. L. (1990). Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program. Fertil Steril, 53(4), 673–676. https://doi.org/10.1016/s0015-0282(16)53462-1
Acosta, A. A., S. Oehninger, J. Hammer, S. J. Muasher, H. M. Liang, and D. L. Jones. “Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program.Fertil Steril 53, no. 4 (April 1990): 673–76. https://doi.org/10.1016/s0015-0282(16)53462-1.
Acosta AA, Oehninger S, Hammer J, Muasher SJ, Liang HM, Jones DL. Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program. Fertil Steril. 1990 Apr;53(4):673–6.
Acosta, A. A., et al. “Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program.Fertil Steril, vol. 53, no. 4, Apr. 1990, pp. 673–76. Pubmed, doi:10.1016/s0015-0282(16)53462-1.
Acosta AA, Oehninger S, Hammer J, Muasher SJ, Liang HM, Jones DL. Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program. Fertil Steril. 1990 Apr;53(4):673–676.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

April 1990

Volume

53

Issue

4

Start / End Page

673 / 676

Location

United States

Related Subject Headings

  • Prognosis
  • Progesterone
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Norway
  • Menstrual Cycle
  • Humans
  • Fertilization in Vitro
  • Female
  • Estradiol