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High-dose follicle-stimulating hormone (FSH) ovarian stimulation in low-responder patients for in vitro fertilization.

Publication ,  Journal Article
Hofmann, GE; Toner, JP; Muasher, SJ; Jones, GS
Published in: J In Vitro Fert Embryo Transf
October 1989

Follicle-stimulating hormone (FSH) was used in high doses (6 ampoules/day:6FSH) for ovarian hyperstimulation for in vitro fertilization in women with a previous poor response to stimulation with the equivalent of "4FSH." Luteinizing hormone levels did not differ between stimulations, but both FSH and estradiol levels were higher in the 6FSH compared to the 4FSH cycle. There were fewer cancellations in the 6FSH cycle, but similar numbers of preovulatory oocytes were retrieved, fertilized, and transferred. The pregnancy rates per attempt and retrieval were higher in the 6FSH cycle. We conclude that raising and maintaining FSH levels during stimulation in low responders reduced cancellations and may improve in vitro fertilization outcome.

Duke Scholars

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Published In

J In Vitro Fert Embryo Transf

DOI

ISSN

0740-7769

Publication Date

October 1989

Volume

6

Issue

5

Start / End Page

285 / 289

Location

United States

Related Subject Headings

  • Ovarian Follicle
  • Luteinizing Hormone
  • Infertility, Female
  • Humans
  • Follicle Stimulating Hormone
  • Fertilization in Vitro
  • Female
  • Estradiol
  • Dose-Response Relationship, Drug
  • Adult
 

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Hofmann, G. E., Toner, J. P., Muasher, S. J., & Jones, G. S. (1989). High-dose follicle-stimulating hormone (FSH) ovarian stimulation in low-responder patients for in vitro fertilization. J In Vitro Fert Embryo Transf, 6(5), 285–289. https://doi.org/10.1007/BF01139183
Hofmann, G. E., J. P. Toner, S. J. Muasher, and G. S. Jones. “High-dose follicle-stimulating hormone (FSH) ovarian stimulation in low-responder patients for in vitro fertilization.J In Vitro Fert Embryo Transf 6, no. 5 (October 1989): 285–89. https://doi.org/10.1007/BF01139183.
Hofmann GE, Toner JP, Muasher SJ, Jones GS. High-dose follicle-stimulating hormone (FSH) ovarian stimulation in low-responder patients for in vitro fertilization. J In Vitro Fert Embryo Transf. 1989 Oct;6(5):285–9.
Hofmann, G. E., et al. “High-dose follicle-stimulating hormone (FSH) ovarian stimulation in low-responder patients for in vitro fertilization.J In Vitro Fert Embryo Transf, vol. 6, no. 5, Oct. 1989, pp. 285–89. Pubmed, doi:10.1007/BF01139183.
Hofmann GE, Toner JP, Muasher SJ, Jones GS. High-dose follicle-stimulating hormone (FSH) ovarian stimulation in low-responder patients for in vitro fertilization. J In Vitro Fert Embryo Transf. 1989 Oct;6(5):285–289.

Published In

J In Vitro Fert Embryo Transf

DOI

ISSN

0740-7769

Publication Date

October 1989

Volume

6

Issue

5

Start / End Page

285 / 289

Location

United States

Related Subject Headings

  • Ovarian Follicle
  • Luteinizing Hormone
  • Infertility, Female
  • Humans
  • Follicle Stimulating Hormone
  • Fertilization in Vitro
  • Female
  • Estradiol
  • Dose-Response Relationship, Drug
  • Adult