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Nanoshell-enabled photonics-based imaging and therapy of cancer.

Publication ,  Journal Article
Loo, C; Lin, A; Hirsch, L; Lee, M-H; Barton, J; Halas, N; West, J; Drezek, R
Published in: Technology in cancer research & treatment
February 2004

Metal nanoshells are a novel type of composite spherical nanoparticle consisting of a dielectric core covered by a thin metallic shell which is typically gold. Nanoshells possess highly favorable optical and chemical properties for biomedical imaging and therapeutic applications. By varying the relative the dimensions of the core and the shell, the optical resonance of these nanoparticles can be precisely and systematically varied over a broad region ranging from the near-UV to the mid-infrared. This range includes the near-infrared (NIR) wavelength region where tissue transmissivity peaks. In addition to spectral tunability, nanoshells offer other advantages over conventional organic dyes including improved optical properties and reduced susceptibility to chemical/thermal denaturation. Furthermore, the same conjugation protocols used to bind biomolecules to gold colloid are easily modified for nanoshells. In this article, we first review the synthesis of gold nanoshells and illustrate how the core/shell ratio and overall size of a nanoshell influences its scattering and absorption properties. We then describe several examples of nanoshell-based diagnostic and therapeutic approaches including the development of nanoshell bioconjugates for molecular imaging, the use of scattering nanoshells as contrast agents for optical coherence tomography (OCT), and the use of absorbing nanoshells in NIR thermal therapy of tumors.

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Published In

Technology in cancer research & treatment

DOI

EISSN

1533-0338

ISSN

1533-0346

Publication Date

February 2004

Volume

3

Issue

1

Start / End Page

33 / 40

Related Subject Headings

  • Silicon Dioxide
  • Phototherapy
  • Oncology & Carcinogenesis
  • Nanotechnology
  • Microscopy, Electron
  • Infrared Rays
  • Humans
  • Gold
  • Cell Line, Tumor
  • Breast Neoplasms
 

Citation

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Loo, C., Lin, A., Hirsch, L., Lee, M.-H., Barton, J., Halas, N., … Drezek, R. (2004). Nanoshell-enabled photonics-based imaging and therapy of cancer. Technology in Cancer Research & Treatment, 3(1), 33–40. https://doi.org/10.1177/153303460400300104
Loo, Christopher, Alex Lin, Leon Hirsch, Min-Ho Lee, Jennifer Barton, Naomi Halas, Jennifer West, and Rebekah Drezek. “Nanoshell-enabled photonics-based imaging and therapy of cancer.Technology in Cancer Research & Treatment 3, no. 1 (February 2004): 33–40. https://doi.org/10.1177/153303460400300104.
Loo C, Lin A, Hirsch L, Lee M-H, Barton J, Halas N, et al. Nanoshell-enabled photonics-based imaging and therapy of cancer. Technology in cancer research & treatment. 2004 Feb;3(1):33–40.
Loo, Christopher, et al. “Nanoshell-enabled photonics-based imaging and therapy of cancer.Technology in Cancer Research & Treatment, vol. 3, no. 1, Feb. 2004, pp. 33–40. Epmc, doi:10.1177/153303460400300104.
Loo C, Lin A, Hirsch L, Lee M-H, Barton J, Halas N, West J, Drezek R. Nanoshell-enabled photonics-based imaging and therapy of cancer. Technology in cancer research & treatment. 2004 Feb;3(1):33–40.
Journal cover image

Published In

Technology in cancer research & treatment

DOI

EISSN

1533-0338

ISSN

1533-0346

Publication Date

February 2004

Volume

3

Issue

1

Start / End Page

33 / 40

Related Subject Headings

  • Silicon Dioxide
  • Phototherapy
  • Oncology & Carcinogenesis
  • Nanotechnology
  • Microscopy, Electron
  • Infrared Rays
  • Humans
  • Gold
  • Cell Line, Tumor
  • Breast Neoplasms