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Tunable drug release from hydrolytically degradable layer-by-layer thin films

Publication ,  Journal Article
Wood, KC; Boedicker, JQ; Lynn, DM; Hammond, PT
Published in: Langmuir
February 15, 2005

The development of new thin film fabrication techniques that allow for precise control of degradation and drug release properties could represent an important advance in the fields of drug delivery and biomedicine. Polyelectrolyte layer-by-layer (LBL) thin films can be assembled with nanometer scale control over spatial architecture and morphology, yet very little work has focused on the deconstruction of these ordered thin films for controlled release applications. In this study, hydrolytically degradable LBL thin films are constructed by alternately depositing a degradable poly(β-amino ester) (polymer 1) and a series of model therapeutic polysaccharides (heparin, low molecular weight heparin, and chondroitin sulfate). These films exhibit pH-dependent, pseudo-first-order degradation and release behavior. The highly versatile and tunable properties of these materials make them exciting candidates for the controlled release of a wide spectrum of therapeutics.

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Published In

Langmuir

DOI

ISSN

0743-7463

Publication Date

February 15, 2005

Volume

21

Issue

4

Start / End Page

1603 / 1609

Related Subject Headings

  • Chemical Physics
 

Citation

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Wood, K. C., Boedicker, J. Q., Lynn, D. M., & Hammond, P. T. (2005). Tunable drug release from hydrolytically degradable layer-by-layer thin films. Langmuir, 21(4), 1603–1609. https://doi.org/10.1021/la0476480
Wood, K. C., J. Q. Boedicker, D. M. Lynn, and P. T. Hammond. “Tunable drug release from hydrolytically degradable layer-by-layer thin films.” Langmuir 21, no. 4 (February 15, 2005): 1603–9. https://doi.org/10.1021/la0476480.
Wood KC, Boedicker JQ, Lynn DM, Hammond PT. Tunable drug release from hydrolytically degradable layer-by-layer thin films. Langmuir. 2005 Feb 15;21(4):1603–9.
Wood, K. C., et al. “Tunable drug release from hydrolytically degradable layer-by-layer thin films.” Langmuir, vol. 21, no. 4, Feb. 2005, pp. 1603–09. Scopus, doi:10.1021/la0476480.
Wood KC, Boedicker JQ, Lynn DM, Hammond PT. Tunable drug release from hydrolytically degradable layer-by-layer thin films. Langmuir. 2005 Feb 15;21(4):1603–1609.
Journal cover image

Published In

Langmuir

DOI

ISSN

0743-7463

Publication Date

February 15, 2005

Volume

21

Issue

4

Start / End Page

1603 / 1609

Related Subject Headings

  • Chemical Physics