Skip to main content

Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.

Publication ,  Journal Article
Kelemen, LE; Wang, Q; Dinu, I; Vierkant, RA; Tsai, Y-Y; Cunningham, JM; Phelan, CM; Fridley, BL; Amankwah, EK; Iversen, ES; Berchuck, A ...
Published in: Front Genet
2012

ATIC, SHMT2, and SLC46A1 have essential roles in one-carbon (1-C) transfer. The authors examined whether associations between ovarian carcinoma and 15 variants in these genes are modified by regular multivitamin use, a source of 1-C donors, among Caucasian participants from two US case-control studies. Using a phased study design, variant-by-multivitamin interactions were tested, and associations between variants and ovarian carcinoma were reported stratified by multivitamin supplement use. Per-allele risk associations were modified by multivitamin use at six variants among 655 cases and 920 controls (Phase 1). In a larger sample of 968 cases and 1,265 controls (Phases 1 and 2), interactions were significant (P ≤ 0.03) for two variants, particularly among regular multivitamin users: ATIC rs7586969 [odds ratio (OR) = 0.7, 95% confidence interval (CI) = 0.6-0.9] and ATIC rs16853834 (OR = 1.5, 95% CI = 1.1-2.0). The two ATIC single nucleotide polymorphisms (SNPs) did not share the same haplotype; however, the haplotypes they comprised mirrored their SNP risk associations among regular multivitamin supplement users. A multi-variant analysis was also performed by comparing the observed likelihood ratio test statistic from adjusted models with and without the two ATIC variant-by-multivitamin interaction terms with a null distribution of test statistics generated by permuting case status 10,000 times. The corresponding observed P value of 0.001 was more extreme than the permutation-derived P value of 0.009, suggesting rejection of the null hypothesis of no association. In summary, there is little statistical evidence that the 15 variants are independently associated with risk of ovarian carcinoma. However, the statistical interaction of ATIC variants with regular multivitamin intake, when evaluated at both the SNP and gene level, may support these findings as relevant to ovarian health and disease processes.

Duke Scholars

Published In

Front Genet

DOI

EISSN

1664-8021

Publication Date

2012

Volume

3

Start / End Page

33

Location

Switzerland

Related Subject Headings

  • 3105 Genetics
  • 1801 Law
  • 1103 Clinical Sciences
  • 0604 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kelemen, L. E., Wang, Q., Dinu, I., Vierkant, R. A., Tsai, Y.-Y., Cunningham, J. M., … Sellers, T. A. (2012). Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma. Front Genet, 3, 33. https://doi.org/10.3389/fgene.2012.00033
Kelemen, Linda E., Qinggang Wang, Irina Dinu, Robert A. Vierkant, Ya-Yu Tsai, Julie M. Cunningham, Catherine M. Phelan, et al. “Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.Front Genet 3 (2012): 33. https://doi.org/10.3389/fgene.2012.00033.
Kelemen LE, Wang Q, Dinu I, Vierkant RA, Tsai Y-Y, Cunningham JM, et al. Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma. Front Genet. 2012;3:33.
Kelemen, Linda E., et al. “Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.Front Genet, vol. 3, 2012, p. 33. Pubmed, doi:10.3389/fgene.2012.00033.
Kelemen LE, Wang Q, Dinu I, Vierkant RA, Tsai Y-Y, Cunningham JM, Phelan CM, Fridley BL, Amankwah EK, Iversen ES, Berchuck A, Schildkraut JM, Goode EL, Sellers TA. Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma. Front Genet. 2012;3:33.

Published In

Front Genet

DOI

EISSN

1664-8021

Publication Date

2012

Volume

3

Start / End Page

33

Location

Switzerland

Related Subject Headings

  • 3105 Genetics
  • 1801 Law
  • 1103 Clinical Sciences
  • 0604 Genetics