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Gene therapy for the prevention of vein graft disease.

Publication ,  Journal Article
Southerland, KW; Frazier, SB; Bowles, DE; Milano, CA; Kontos, CD
Published in: Transl Res
April 2013

Ischemic cardiovascular disease remains the leading cause of death worldwide. Despite advances in the medical management of atherosclerosis over the past several decades, many patients require arterial revascularization to reduce mortality and alleviate ischemic symptoms. Technological advancements have led to dramatic increases in the use of percutaneous and endovascular approaches, yet surgical revascularization (bypass surgery) with autologous vein grafts remains a mainstay of therapy for both coronary and peripheral artery disease. Although bypass surgery is highly efficacious in the short term, long-term outcomes are limited by relatively high failure rates as a result of intimal hyperplasia, which is a common feature of vein graft disease. The supply of native veins is limited, and many individuals require multiple grafts and repeat procedures. The need to prevent vein graft failure has led to great interest in gene therapy approaches to this problem. Bypass grafting presents an ideal opportunity for gene therapy, as surgically harvested vein grafts can be treated with gene delivery vectors ex vivo, thereby maximizing gene delivery while minimizing the potential for systemic toxicity and targeting the pathogenesis of vein graft disease at its onset. Here we will review the pathogenesis of vein graft disease and discuss vector delivery strategies and potential molecular targets for its prevention. We will summarize the preclinical and clinical literature on gene therapy in vein grafting and discuss additional considerations for future therapies to prevent vein graft disease.

Duke Scholars

Published In

Transl Res

DOI

EISSN

1878-1810

Publication Date

April 2013

Volume

161

Issue

4

Start / End Page

321 / 338

Location

United States

Related Subject Headings

  • Veins
  • Humans
  • Genetic Vectors
  • Genetic Therapy
  • General Clinical Medicine
  • Gene Transfer Techniques
  • Clinical Trials as Topic
  • Blood Vessel Prosthesis
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Southerland, K. W., Frazier, S. B., Bowles, D. E., Milano, C. A., & Kontos, C. D. (2013). Gene therapy for the prevention of vein graft disease. Transl Res, 161(4), 321–338. https://doi.org/10.1016/j.trsl.2012.12.003
Southerland, Kevin W., Sarah B. Frazier, Dawn E. Bowles, Carmelo A. Milano, and Christopher D. Kontos. “Gene therapy for the prevention of vein graft disease.Transl Res 161, no. 4 (April 2013): 321–38. https://doi.org/10.1016/j.trsl.2012.12.003.
Southerland KW, Frazier SB, Bowles DE, Milano CA, Kontos CD. Gene therapy for the prevention of vein graft disease. Transl Res. 2013 Apr;161(4):321–38.
Southerland, Kevin W., et al. “Gene therapy for the prevention of vein graft disease.Transl Res, vol. 161, no. 4, Apr. 2013, pp. 321–38. Pubmed, doi:10.1016/j.trsl.2012.12.003.
Southerland KW, Frazier SB, Bowles DE, Milano CA, Kontos CD. Gene therapy for the prevention of vein graft disease. Transl Res. 2013 Apr;161(4):321–338.
Journal cover image

Published In

Transl Res

DOI

EISSN

1878-1810

Publication Date

April 2013

Volume

161

Issue

4

Start / End Page

321 / 338

Location

United States

Related Subject Headings

  • Veins
  • Humans
  • Genetic Vectors
  • Genetic Therapy
  • General Clinical Medicine
  • Gene Transfer Techniques
  • Clinical Trials as Topic
  • Blood Vessel Prosthesis
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology