Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24.
Publication
, Journal Article
Krishnan, KR; Miller, MN; Helms, MJ; Reed, D; Ritchie, JC; Nemeroff, CB; Carroll, BJ
Published in: Eur Arch Psychiatry Clin Neurosci
1993
The authors examined the dose response relationship between plasma ACTH and cortisol concentrations after the administration of various doses of ACTH1-24 (0.025 micrograms, 0.125 micrograms, 0.25 micrograms, 1 microgram, 250 micrograms) in dexamethasone-suppressed normal volunteers. A logarithmic dose-response relationship between the dose of ACTH administered and plasma cortisol concentration was found. Although there was considerable variability in plasma ACTH concentrations, there was, however, a definite correlation between area under the curve for ACTH and area under the curve for cortisol after the various doses of ACTH.
Duke Scholars
Published In
Eur Arch Psychiatry Clin Neurosci
DOI
ISSN
0940-1334
Publication Date
1993
Volume
242
Issue
4
Start / End Page
240 / 243
Location
Germany
Related Subject Headings
- Reference Values
- Psychiatry
- Pituitary-Adrenal System
- Male
- Hydrocortisone
- Humans
- Double-Blind Method
- Dose-Response Relationship, Drug
- Cosyntropin
- Adult
Citation
APA
Chicago
ICMJE
MLA
NLM
Krishnan, K. R., Miller, M. N., Helms, M. J., Reed, D., Ritchie, J. C., Nemeroff, C. B., & Carroll, B. J. (1993). Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24. Eur Arch Psychiatry Clin Neurosci, 242(4), 240–243. https://doi.org/10.1007/BF02189969
Krishnan, K. R., M. N. Miller, M. J. Helms, D. Reed, J. C. Ritchie, C. B. Nemeroff, and B. J. Carroll. “Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24.” Eur Arch Psychiatry Clin Neurosci 242, no. 4 (1993): 240–43. https://doi.org/10.1007/BF02189969.
Krishnan KR, Miller MN, Helms MJ, Reed D, Ritchie JC, Nemeroff CB, et al. Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24. Eur Arch Psychiatry Clin Neurosci. 1993;242(4):240–3.
Krishnan, K. R., et al. “Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24.” Eur Arch Psychiatry Clin Neurosci, vol. 242, no. 4, 1993, pp. 240–43. Pubmed, doi:10.1007/BF02189969.
Krishnan KR, Miller MN, Helms MJ, Reed D, Ritchie JC, Nemeroff CB, Carroll BJ. Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24. Eur Arch Psychiatry Clin Neurosci. 1993;242(4):240–243.
Published In
Eur Arch Psychiatry Clin Neurosci
DOI
ISSN
0940-1334
Publication Date
1993
Volume
242
Issue
4
Start / End Page
240 / 243
Location
Germany
Related Subject Headings
- Reference Values
- Psychiatry
- Pituitary-Adrenal System
- Male
- Hydrocortisone
- Humans
- Double-Blind Method
- Dose-Response Relationship, Drug
- Cosyntropin
- Adult