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Fast feedback regulation of ACTH by cortisol.

Publication ,  Journal Article
Krishnan, KR; Ritchie, JC; Manepalli, AN; Saunders, W; Li, SW; Venkataraman, S; Nemeroff, CB; Carroll, BJ
Published in: Prog Neuropsychopharmacol Biol Psychiatry
1991

1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

Duke Scholars

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

ISSN

0278-5846

Publication Date

1991

Volume

15

Issue

4

Start / End Page

523 / 529

Location

England

Related Subject Headings

  • Psychiatry
  • Male
  • Hydrocortisone
  • Humans
  • Feedback
  • Adrenocorticotropic Hormone
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
  • 17 Psychology and Cognitive Sciences
 

Citation

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Krishnan, K. R., Ritchie, J. C., Manepalli, A. N., Saunders, W., Li, S. W., Venkataraman, S., … Carroll, B. J. (1991). Fast feedback regulation of ACTH by cortisol. Prog Neuropsychopharmacol Biol Psychiatry, 15(4), 523–529. https://doi.org/10.1016/0278-5846(91)90027-x
Krishnan, K. R., J. C. Ritchie, A. N. Manepalli, W. Saunders, S. W. Li, S. Venkataraman, C. B. Nemeroff, and B. J. Carroll. “Fast feedback regulation of ACTH by cortisol.Prog Neuropsychopharmacol Biol Psychiatry 15, no. 4 (1991): 523–29. https://doi.org/10.1016/0278-5846(91)90027-x.
Krishnan KR, Ritchie JC, Manepalli AN, Saunders W, Li SW, Venkataraman S, et al. Fast feedback regulation of ACTH by cortisol. Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(4):523–9.
Krishnan, K. R., et al. “Fast feedback regulation of ACTH by cortisol.Prog Neuropsychopharmacol Biol Psychiatry, vol. 15, no. 4, 1991, pp. 523–29. Pubmed, doi:10.1016/0278-5846(91)90027-x.
Krishnan KR, Ritchie JC, Manepalli AN, Saunders W, Li SW, Venkataraman S, Nemeroff CB, Carroll BJ. Fast feedback regulation of ACTH by cortisol. Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(4):523–529.
Journal cover image

Published In

Prog Neuropsychopharmacol Biol Psychiatry

DOI

ISSN

0278-5846

Publication Date

1991

Volume

15

Issue

4

Start / End Page

523 / 529

Location

England

Related Subject Headings

  • Psychiatry
  • Male
  • Hydrocortisone
  • Humans
  • Feedback
  • Adrenocorticotropic Hormone
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
  • 17 Psychology and Cognitive Sciences