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Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.

Publication ,  Journal Article
Kelly, P; Casey, PJ; Meigs, TE
Published in: Biochemistry
June 12, 2007

The G12 subfamily of heterotrimeric G proteins has been the subject of intense scientific interest for more than 15 years. During this period, studies have revealed more than 20 potential G12-interacting proteins and numerous signaling axes emanating from the G12 proteins, Galpha12 and Galpha13. In addition, more recent studies have begun to illuminate the various and sundry functions that the G12 subfamily plays in biology. In this review, we summarize the diverse range of proteins that have been identified as Galpha12 and/or Galpha13 interactors and describe ongoing studies designed to dissect the biological roles of specific Galpha-effector protein interactions. Further, we describe and discuss the expanding role of G12 proteins in the biology of cells, focusing on the distinct properties of this subfamily in regulating cell proliferation, cell migration, and metastatic invasion.

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Published In

Biochemistry

DOI

ISSN

0006-2960

Publication Date

June 12, 2007

Volume

46

Issue

23

Start / End Page

6677 / 6687

Location

United States

Related Subject Headings

  • Tight Junctions
  • Protein-Tyrosine Kinases
  • Neoplasm Metastasis
  • Humans
  • GTP-Binding Protein alpha Subunits, G12-G13
  • Cell Movement
  • Cell Division
  • Cadherins
  • Biochemistry & Molecular Biology
  • Animals
 

Citation

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Kelly, P., Casey, P. J., & Meigs, T. E. (2007). Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry, 46(23), 6677–6687. https://doi.org/10.1021/bi700235f
Kelly, Patrick, Patrick J. Casey, and Thomas E. Meigs. “Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.Biochemistry 46, no. 23 (June 12, 2007): 6677–87. https://doi.org/10.1021/bi700235f.
Kelly P, Casey PJ, Meigs TE. Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry. 2007 Jun 12;46(23):6677–87.
Kelly, Patrick, et al. “Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.Biochemistry, vol. 46, no. 23, June 2007, pp. 6677–87. Pubmed, doi:10.1021/bi700235f.
Kelly P, Casey PJ, Meigs TE. Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. Biochemistry. 2007 Jun 12;46(23):6677–6687.
Journal cover image

Published In

Biochemistry

DOI

ISSN

0006-2960

Publication Date

June 12, 2007

Volume

46

Issue

23

Start / End Page

6677 / 6687

Location

United States

Related Subject Headings

  • Tight Junctions
  • Protein-Tyrosine Kinases
  • Neoplasm Metastasis
  • Humans
  • GTP-Binding Protein alpha Subunits, G12-G13
  • Cell Movement
  • Cell Division
  • Cadherins
  • Biochemistry & Molecular Biology
  • Animals