Androgen receptor activation by G(s) signaling in prostate cancer cells.
Publication
, Journal Article
Kasbohm, EA; Guo, R; Yowell, CW; Bagchi, G; Kelly, P; Arora, P; Casey, PJ; Daaka, Y
Published in: J Biol Chem
March 25, 2005
The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen ablative therapy and mediates growth of androgen-insensitive prostate cancer cells, suggesting it is activated by nonandrogenic factors. We demonstrate that activated alpha subunit of heterotrimeric guanine nucleotide-binding G(s) protein activates the AR in prostate cancer cells and also synergizes with low concentration of androgen to more fully activate the AR. The G alpha(s) activates protein kinase A, which is required for the nuclear partition and activation of AR. These data suggest a role for G alpha(s) and PKA in the transactivation of AR in prostate cancer cells under the environment of reduced androgen levels.
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Published In
J Biol Chem
DOI
ISSN
0021-9258
Publication Date
March 25, 2005
Volume
280
Issue
12
Start / End Page
11583 / 11589
Location
United States
Related Subject Headings
- Signal Transduction
- Receptors, Androgen
- Receptors, Adrenergic, beta-2
- Prostatic Neoplasms
- Male
- Isoproterenol
- Humans
- GTP-Binding Protein alpha Subunits, Gs
- Dihydrotestosterone
- Cyclic AMP-Dependent Protein Kinases
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Kasbohm, E. A., Guo, R., Yowell, C. W., Bagchi, G., Kelly, P., Arora, P., … Daaka, Y. (2005). Androgen receptor activation by G(s) signaling in prostate cancer cells. J Biol Chem, 280(12), 11583–11589. https://doi.org/10.1074/jbc.M414423200
Kasbohm, Elizabeth A., Rishu Guo, Charles W. Yowell, Gargi Bagchi, Patrick Kelly, Puneeta Arora, Patrick J. Casey, and Yehia Daaka. “Androgen receptor activation by G(s) signaling in prostate cancer cells.” J Biol Chem 280, no. 12 (March 25, 2005): 11583–89. https://doi.org/10.1074/jbc.M414423200.
Kasbohm EA, Guo R, Yowell CW, Bagchi G, Kelly P, Arora P, et al. Androgen receptor activation by G(s) signaling in prostate cancer cells. J Biol Chem. 2005 Mar 25;280(12):11583–9.
Kasbohm, Elizabeth A., et al. “Androgen receptor activation by G(s) signaling in prostate cancer cells.” J Biol Chem, vol. 280, no. 12, Mar. 2005, pp. 11583–89. Pubmed, doi:10.1074/jbc.M414423200.
Kasbohm EA, Guo R, Yowell CW, Bagchi G, Kelly P, Arora P, Casey PJ, Daaka Y. Androgen receptor activation by G(s) signaling in prostate cancer cells. J Biol Chem. 2005 Mar 25;280(12):11583–11589.
Published In
J Biol Chem
DOI
ISSN
0021-9258
Publication Date
March 25, 2005
Volume
280
Issue
12
Start / End Page
11583 / 11589
Location
United States
Related Subject Headings
- Signal Transduction
- Receptors, Androgen
- Receptors, Adrenergic, beta-2
- Prostatic Neoplasms
- Male
- Isoproterenol
- Humans
- GTP-Binding Protein alpha Subunits, Gs
- Dihydrotestosterone
- Cyclic AMP-Dependent Protein Kinases