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Mapping autism risk loci using genetic linkage and chromosomal rearrangements.

Publication ,  Journal Article
Autism Genome Project Consortium, ; Szatmari, P; Paterson, AD; Zwaigenbaum, L; Roberts, W; Brian, J; Liu, X-Q; Vincent, JB; Skaug, JL; Senman, L ...
Published in: Nat Genet
March 2007

Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 [corrected] families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs.

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Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

March 2007

Volume

39

Issue

3

Start / End Page

319 / 328

Location

United States

Related Subject Headings

  • Risk Factors
  • Male
  • Lod Score
  • Humans
  • Genetic Variation
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Genetic Linkage
  • Female
  • Family
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Autism Genome Project Consortium, ., Szatmari, P., Paterson, A. D., Zwaigenbaum, L., Roberts, W., Brian, J., … Meyer, K. J. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet, 39(3), 319–328. https://doi.org/10.1038/ng1985
Autism Genome Project Consortium, Kacie J., Peter Szatmari, Andrew D. Paterson, Lonnie Zwaigenbaum, Wendy Roberts, Jessica Brian, Xiao-Qing Liu, et al. “Mapping autism risk loci using genetic linkage and chromosomal rearrangements.Nat Genet 39, no. 3 (March 2007): 319–28. https://doi.org/10.1038/ng1985.
Autism Genome Project Consortium, Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, et al. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 2007 Mar;39(3):319–28.
Autism Genome Project Consortium, Kacie J., et al. “Mapping autism risk loci using genetic linkage and chromosomal rearrangements.Nat Genet, vol. 39, no. 3, Mar. 2007, pp. 319–28. Pubmed, doi:10.1038/ng1985.
Autism Genome Project Consortium, Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu X-Q, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, Buxbaum JD, Davis KL, Hollander E, Silverman JM, Hallmayer J, Lotspeich L, Sutcliffe JS, Haines JL, Folstein SE, Piven J, Wassink TH, Sheffield V, Geschwind DH, Bucan M, Brown WT, Cantor RM, Constantino JN, Gilliam TC, Herbert M, Lajonchere C, Ledbetter DH, Lese-Martin C, Miller J, Nelson S, Samango-Sprouse CA, Spence S, State M, Tanzi RE, Coon H, Dawson G, Devlin B, Estes A, Flodman P, Klei L, McMahon WM, Minshew N, Munson J, Korvatska E, Rodier PM, Schellenberg GD, Smith M, Spence MA, Stodgell C, Tepper PG, Wijsman EM, Yu C-E, Rogé B, Mantoulan C, Wittemeyer K, Poustka A, Felder B, Klauck SM, Schuster C, Poustka F, Bölte S, Feineis-Matthews S, Herbrecht E, Schmötzer G, Tsiantis J, Papanikolaou K, Maestrini E, Bacchelli E, Blasi F, Carone S, Toma C, Van Engeland H, de Jonge M, Kemner C, Koop F, Langemeijer M, Hijmans C, Staal WG, Baird G, Bolton PF, Rutter ML, Weisblatt E, Green J, Aldred C, Wilkinson J-A, Pickles A, Le Couteur A, Berney T, McConachie H, Bailey AJ, Francis K, Honeyman G, Hutchinson A, Parr JR, Wallace S, Monaco AP, Barnby G, Kobayashi K, Lamb JA, Sousa I, Sykes N, Cook EH, Guter SJ, Leventhal BL, Salt J, Lord C, Corsello C, Hus V, Weeks DE, Volkmar F, Tauber M, Fombonne E, Shih A, Meyer KJ. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 2007 Mar;39(3):319–328.

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

March 2007

Volume

39

Issue

3

Start / End Page

319 / 328

Location

United States

Related Subject Headings

  • Risk Factors
  • Male
  • Lod Score
  • Humans
  • Genetic Variation
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Genetic Linkage
  • Female
  • Family