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Improved doubly robust estimation when data are monotonely coarsened, with application to longitudinal studies with dropout.

Publication ,  Journal Article
Tsiatis, AA; Davidian, M; Cao, W
Published in: Biometrics
June 2011

A routine challenge is that of making inference on parameters in a statistical model of interest from longitudinal data subject to dropout, which are a special case of the more general setting of monotonely coarsened data. Considerable recent attention has focused on doubly robust (DR) estimators, which in this context involve positing models for both the missingness (more generally, coarsening) mechanism and aspects of the distribution of the full data, that have the appealing property of yielding consistent inferences if only one of these models is correctly specified. DR estimators have been criticized for potentially disastrous performance when both of these models are even only mildly misspecified. We propose a DR estimator applicable in general monotone coarsening problems that achieves comparable or improved performance relative to existing DR methods, which we demonstrate via simulation studies and by application to data from an AIDS clinical trial.

Duke Scholars

Published In

Biometrics

DOI

EISSN

1541-0420

Publication Date

June 2011

Volume

67

Issue

2

Start / End Page

536 / 545

Location

England

Related Subject Headings

  • Statistics & Probability
  • Statistical Distributions
  • Models, Statistical
  • Longitudinal Studies
  • Humans
  • Computer Simulation
  • Biometry
  • Acquired Immunodeficiency Syndrome
  • 4905 Statistics
  • 0199 Other Mathematical Sciences
 

Citation

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Tsiatis, A. A., Davidian, M., & Cao, W. (2011). Improved doubly robust estimation when data are monotonely coarsened, with application to longitudinal studies with dropout. Biometrics, 67(2), 536–545. https://doi.org/10.1111/j.1541-0420.2010.01476.x
Tsiatis, Anastasios A., Marie Davidian, and Weihua Cao. “Improved doubly robust estimation when data are monotonely coarsened, with application to longitudinal studies with dropout.Biometrics 67, no. 2 (June 2011): 536–45. https://doi.org/10.1111/j.1541-0420.2010.01476.x.
Tsiatis, Anastasios A., et al. “Improved doubly robust estimation when data are monotonely coarsened, with application to longitudinal studies with dropout.Biometrics, vol. 67, no. 2, June 2011, pp. 536–45. Pubmed, doi:10.1111/j.1541-0420.2010.01476.x.
Journal cover image

Published In

Biometrics

DOI

EISSN

1541-0420

Publication Date

June 2011

Volume

67

Issue

2

Start / End Page

536 / 545

Location

England

Related Subject Headings

  • Statistics & Probability
  • Statistical Distributions
  • Models, Statistical
  • Longitudinal Studies
  • Humans
  • Computer Simulation
  • Biometry
  • Acquired Immunodeficiency Syndrome
  • 4905 Statistics
  • 0199 Other Mathematical Sciences