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Semiparametric estimation of treatment effect in a pretest-posttest study.

Publication ,  Journal Article
Leon, S; Tsiatis, AA; Davidian, M
Published in: Biometrics
December 2003

Inference on treatment effects in a pretest-posttest study is a routine objective in medicine, public health, and other fields. A number of approaches have been advocated. We take a semiparametric perspective, making no assumptions about the distributions of baseline and posttest responses. By representing the situation in terms of counterfactual random variables, we exploit recent developments in the literature on missing data and causal inference, to derive the class of all consistent treatment effect estimators, identify the most efficient such estimator, and outline strategies for implementation of estimators that may improve on popular methods. We demonstrate the methods and their properties via simulation and by application to a data set from an HIV clinical trial.

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Published In

Biometrics

DOI

ISSN

0006-341X

Publication Date

December 2003

Volume

59

Issue

4

Start / End Page

1046 / 1055

Location

England

Related Subject Headings

  • Statistics, Nonparametric
  • Statistics & Probability
  • Randomized Controlled Trials as Topic
  • Models, Statistical
  • Humans
  • HIV Infections
  • Computer Simulation
  • Clinical Trials as Topic
  • CD4 Lymphocyte Count
  • Biometry
 

Citation

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Leon, S., Tsiatis, A. A., & Davidian, M. (2003). Semiparametric estimation of treatment effect in a pretest-posttest study. Biometrics, 59(4), 1046–1055. https://doi.org/10.1111/j.0006-341x.2003.00120.x
Leon, Selene, Anastasios A. Tsiatis, and Marie Davidian. “Semiparametric estimation of treatment effect in a pretest-posttest study.Biometrics 59, no. 4 (December 2003): 1046–55. https://doi.org/10.1111/j.0006-341x.2003.00120.x.
Leon S, Tsiatis AA, Davidian M. Semiparametric estimation of treatment effect in a pretest-posttest study. Biometrics. 2003 Dec;59(4):1046–55.
Leon, Selene, et al. “Semiparametric estimation of treatment effect in a pretest-posttest study.Biometrics, vol. 59, no. 4, Dec. 2003, pp. 1046–55. Pubmed, doi:10.1111/j.0006-341x.2003.00120.x.
Leon S, Tsiatis AA, Davidian M. Semiparametric estimation of treatment effect in a pretest-posttest study. Biometrics. 2003 Dec;59(4):1046–1055.
Journal cover image

Published In

Biometrics

DOI

ISSN

0006-341X

Publication Date

December 2003

Volume

59

Issue

4

Start / End Page

1046 / 1055

Location

England

Related Subject Headings

  • Statistics, Nonparametric
  • Statistics & Probability
  • Randomized Controlled Trials as Topic
  • Models, Statistical
  • Humans
  • HIV Infections
  • Computer Simulation
  • Clinical Trials as Topic
  • CD4 Lymphocyte Count
  • Biometry