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Adjuvant chemotherapy in nonmetastatic osteosarcoma: a Southwest Oncology Group Study.

Publication ,  Journal Article
Herson, J; Sutow, WW; Elder, K; Vietti, TJ; Falletta, JM; Crist, WM; Vats, TS; Miale, T
Published in: Med Pediatr Oncol
1980

This report updates experience with the CONPADRI-I, COMPADRI-II, and COMPADRI-III adjuvant chemotherapy programs for the treatment of nonmetastatic osteosarcoma. A total of 200 patients received one of the three regimens. The analysis of response to treatment is based on disease-free survival time (DFS time). The effect of treatment, age, sex, site of disease involvement, and race on DFS time were investigated. Cox's life-table regression analysis found only sex to have a significant effect on DFS time with males having 1.8 times the risk of recurrence or death per unit time as female patients (P = 0.004). An analysis of the 81 patients still alive and disease-free 18 months after the start of treatment shows significantly longer DFS time for CONPADRI-I than COMPADRI-II patients (P = 0.01). This trend is true for both male (P = 0.12) and female (P = 0.08) patients.

Duke Scholars

Published In

Med Pediatr Oncol

DOI

ISSN

0098-1532

Publication Date

1980

Volume

8

Issue

4

Start / End Page

343 / 352

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk
  • Racial Groups
  • Prognosis
  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Male
  • Humans
  • Follow-Up Studies
 

Citation

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MLA
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Herson, J., Sutow, W. W., Elder, K., Vietti, T. J., Falletta, J. M., Crist, W. M., … Miale, T. (1980). Adjuvant chemotherapy in nonmetastatic osteosarcoma: a Southwest Oncology Group Study. Med Pediatr Oncol, 8(4), 343–352. https://doi.org/10.1002/mpo.2950080405
Herson, J., W. W. Sutow, K. Elder, T. J. Vietti, J. M. Falletta, W. M. Crist, T. S. Vats, and T. Miale. “Adjuvant chemotherapy in nonmetastatic osteosarcoma: a Southwest Oncology Group Study.Med Pediatr Oncol 8, no. 4 (1980): 343–52. https://doi.org/10.1002/mpo.2950080405.
Herson J, Sutow WW, Elder K, Vietti TJ, Falletta JM, Crist WM, et al. Adjuvant chemotherapy in nonmetastatic osteosarcoma: a Southwest Oncology Group Study. Med Pediatr Oncol. 1980;8(4):343–52.
Herson, J., et al. “Adjuvant chemotherapy in nonmetastatic osteosarcoma: a Southwest Oncology Group Study.Med Pediatr Oncol, vol. 8, no. 4, 1980, pp. 343–52. Pubmed, doi:10.1002/mpo.2950080405.
Herson J, Sutow WW, Elder K, Vietti TJ, Falletta JM, Crist WM, Vats TS, Miale T. Adjuvant chemotherapy in nonmetastatic osteosarcoma: a Southwest Oncology Group Study. Med Pediatr Oncol. 1980;8(4):343–352.

Published In

Med Pediatr Oncol

DOI

ISSN

0098-1532

Publication Date

1980

Volume

8

Issue

4

Start / End Page

343 / 352

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk
  • Racial Groups
  • Prognosis
  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Male
  • Humans
  • Follow-Up Studies