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Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty.

Publication ,  Journal Article
Sonkin, PL; Baratz, KH; Frothingham, R; Cobo, LM
Published in: Ophthalmology
December 1992

PURPOSE: A case of acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty is reported. METHODS: Resistance to acyclovir was evident clinically and was confirmed by in vitro susceptibility testing. The susceptibility of the herpes simplex isolates to acyclovir and foscarnet was determined by a dye uptake assay that measured cytopathic effect, and thymidine kinase activity was measured by a plaque autoradiography technique. RESULTS: The viral isolate from postoperative day 22 was susceptible to acyclovir and foscarnet, and showed normal thymidine kinase activity. Isolates from postoperative days 29 and 32 (coinciding with deterioration in clinical appearance) were resistant to acyclovir, susceptible to foscarnet, and deficient in thymidine kinase activity. CONCLUSION: Practitioners should be aware of the potential for the emergence of resistance in this setting; prophylaxis and rational alternate therapies are discussed.

Duke Scholars

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

December 1992

Volume

99

Issue

12

Start / End Page

1805 / 1808

Location

United States

Related Subject Headings

  • Visual Acuity
  • Vero Cells
  • Uveitis
  • Simplexvirus
  • Postoperative Complications
  • Ophthalmology & Optometry
  • Ophthalmic Solutions
  • Middle Aged
  • Microbial Sensitivity Tests
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Sonkin, P. L., Baratz, K. H., Frothingham, R., & Cobo, L. M. (1992). Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty. Ophthalmology, 99(12), 1805–1808. https://doi.org/10.1016/s0161-6420(92)31732-4
Sonkin, P. L., K. H. Baratz, R. Frothingham, and L. M. Cobo. “Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty.Ophthalmology 99, no. 12 (December 1992): 1805–8. https://doi.org/10.1016/s0161-6420(92)31732-4.
Sonkin PL, Baratz KH, Frothingham R, Cobo LM. Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty. Ophthalmology. 1992 Dec;99(12):1805–8.
Sonkin, P. L., et al. “Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty.Ophthalmology, vol. 99, no. 12, Dec. 1992, pp. 1805–08. Pubmed, doi:10.1016/s0161-6420(92)31732-4.
Sonkin PL, Baratz KH, Frothingham R, Cobo LM. Acyclovir-resistant herpes simplex virus keratouveitis after penetrating keratoplasty. Ophthalmology. 1992 Dec;99(12):1805–1808.
Journal cover image

Published In

Ophthalmology

DOI

ISSN

0161-6420

Publication Date

December 1992

Volume

99

Issue

12

Start / End Page

1805 / 1808

Location

United States

Related Subject Headings

  • Visual Acuity
  • Vero Cells
  • Uveitis
  • Simplexvirus
  • Postoperative Complications
  • Ophthalmology & Optometry
  • Ophthalmic Solutions
  • Middle Aged
  • Microbial Sensitivity Tests
  • Male