Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.
Publication
, Journal Article
Kreisberg, JF; Ong, NT; Krishna, A; Joseph, TL; Wang, J; Ong, C; Ooi, HA; Sung, JC; Siew, CC; Chang, GC; Biot, F; Cuccui, J; Wren, BW ...
Published in: Antimicrob Agents Chemother
March 2013
Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy.
Duke Scholars
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
March 2013
Volume
57
Issue
3
Start / End Page
1513 / 1517
Location
United States
Related Subject Headings
- Survival Analysis
- Sulfonylurea Compounds
- Pseudomonas aeruginosa
- Pseudomonas Infections
- Microbiology
- Microbial Sensitivity Tests
- Mice, Inbred BALB C
- Mice
- Melioidosis
- Herbicides
Citation
APA
Chicago
ICMJE
MLA
NLM
Kreisberg, J. F., Ong, N. T., Krishna, A., Joseph, T. L., Wang, J., Ong, C., … Tan, P. (2013). Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrob Agents Chemother, 57(3), 1513–1517. https://doi.org/10.1128/AAC.02327-12
Kreisberg, Jason F., Nicholas T. Ong, Aishwarya Krishna, Thomas L. Joseph, Jing Wang, Catherine Ong, Hui Ann Ooi, et al. “Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.” Antimicrob Agents Chemother 57, no. 3 (March 2013): 1513–17. https://doi.org/10.1128/AAC.02327-12.
Kreisberg JF, Ong NT, Krishna A, Joseph TL, Wang J, Ong C, et al. Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrob Agents Chemother. 2013 Mar;57(3):1513–7.
Kreisberg, Jason F., et al. “Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.” Antimicrob Agents Chemother, vol. 57, no. 3, Mar. 2013, pp. 1513–17. Pubmed, doi:10.1128/AAC.02327-12.
Kreisberg JF, Ong NT, Krishna A, Joseph TL, Wang J, Ong C, Ooi HA, Sung JC, Siew CC, Chang GC, Biot F, Cuccui J, Wren BW, Chan J, Sivalingam SP, Zhang L-H, Verma C, Tan P. Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrob Agents Chemother. 2013 Mar;57(3):1513–1517.
Published In
Antimicrob Agents Chemother
DOI
EISSN
1098-6596
Publication Date
March 2013
Volume
57
Issue
3
Start / End Page
1513 / 1517
Location
United States
Related Subject Headings
- Survival Analysis
- Sulfonylurea Compounds
- Pseudomonas aeruginosa
- Pseudomonas Infections
- Microbiology
- Microbial Sensitivity Tests
- Mice, Inbred BALB C
- Mice
- Melioidosis
- Herbicides