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G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.

Publication ,  Journal Article
Luttrell, LM; van Biesen, T; Hawes, BE; Koch, WJ; Touhara, K; Lefkowitz, RJ
Published in: J Biol Chem
July 14, 1995

The receptors for insulin-like growth factor 1 (IGF1) and insulin are related heterotetrameric proteins which, like the epidermal growth factor (EGF) receptor, possess intrinsic ligand-stimulated tyrosine protein kinase activity. In Rat 1 fibroblasts, stimulation of mitogen-activated protein (MAP) kinase via the IGF1 receptor and the Gi-coupled receptor for lysophosphatidic acid (LPA), but not via the EGF receptor, is sensitive both to pertussis toxin treatment and to cellular expression of a specific G beta gamma subunit-binding peptide. The IGF1, LPA, and EGF receptor-mediated signals are all sensitive to inhibitors of tyrosine protein kinases, require p21ras activation, and are independent of protein kinase C. These data suggest that some tyrosine kinase growth factor receptors (e.g. IGF1 receptor) and classical G protein-coupled receptors (e.g. LPA receptor) employ a similar mechanism for mitogenic signaling that involves both tyrosine phosphorylation and G beta gamma subunits derived from pertussis toxin-sensitive G proteins.

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Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

July 14, 1995

Volume

270

Issue

28

Start / End Page

16495 / 16498

Location

United States

Related Subject Headings

  • Virulence Factors, Bordetella
  • Receptor, IGF Type 1
  • Rats
  • Protein Kinase C
  • Pertussis Toxin
  • GTP-Binding Proteins
  • Enzyme Activation
  • Cells, Cultured
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Biochemistry & Molecular Biology
 

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Luttrell, L. M., van Biesen, T., Hawes, B. E., Koch, W. J., Touhara, K., & Lefkowitz, R. J. (1995). G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J Biol Chem, 270(28), 16495–16498. https://doi.org/10.1074/jbc.270.28.16495
Luttrell, L. M., T. van Biesen, B. E. Hawes, W. J. Koch, K. Touhara, and R. J. Lefkowitz. “G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.J Biol Chem 270, no. 28 (July 14, 1995): 16495–98. https://doi.org/10.1074/jbc.270.28.16495.
Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J Biol Chem. 1995 Jul 14;270(28):16495–8.
Luttrell, L. M., et al. “G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.J Biol Chem, vol. 270, no. 28, July 1995, pp. 16495–98. Pubmed, doi:10.1074/jbc.270.28.16495.
Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J Biol Chem. 1995 Jul 14;270(28):16495–16498.

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

July 14, 1995

Volume

270

Issue

28

Start / End Page

16495 / 16498

Location

United States

Related Subject Headings

  • Virulence Factors, Bordetella
  • Receptor, IGF Type 1
  • Rats
  • Protein Kinase C
  • Pertussis Toxin
  • GTP-Binding Proteins
  • Enzyme Activation
  • Cells, Cultured
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Biochemistry & Molecular Biology